Clare Jenna, Lindley Martin R, Ratcliffe Elizabeth
Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, UK.
School of Health Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney 2052, Australia.
Microorganisms. 2024 Aug 5;12(8):1593. doi: 10.3390/microorganisms12081593.
Chronic wounds are becoming an increasing burden on healthcare services, as they have extended healing times and are susceptible to infection, with many failing to heal, which can lead ultimately to amputation. Due to the additional rise in antimicrobial resistance and emergence of difficult-to-treat , , , , , and spp. (ESKAPE pathogens), novel treatments will soon be required asides from traditional antibiotics. Many natural substances have been identified as having the potential to aid in both preventing infection and increasing the speed of wound closure processes. Manuka honey is already in some cases used as a topical treatment in the form of ointments, which in conjunction with dressings and fish skin grafts are an existing US Food and Drug Administration-approved treatment option. These existing treatment options indicate that fatty acids from fish oil and manuka honey are well tolerated by the body, and if the active components of the treatments were better understood, they could make valuable additions to topical treatment options. This review considers two prominent natural substances with established manufacturing and global distribution-marine based fatty acids (including their metabolites) and manuka honey-their function as antimicrobials and how they can aid in wound repair, two important aspects leading to resolution of chronic wounds.
慢性伤口正给医疗服务带来日益沉重的负担，因为它们愈合时间延长且易受感染，许多伤口无法愈合，最终可能导致截肢。由于抗菌药物耐药性的进一步上升以及难治疗的肠球菌属、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属（ESKAPE病原体）的出现，除了传统抗生素外，很快将需要新的治疗方法。许多天然物质已被确定有可能有助于预防感染和加快伤口愈合进程。麦卢卡蜂蜜在某些情况下已被用作软膏形式的局部治疗药物，与敷料和鱼皮移植一起是美国食品药品监督管理局已批准的现有治疗选择。这些现有的治疗选择表明，鱼油和麦卢卡蜂蜜中的脂肪酸能被人体很好地耐受，如果对这些治疗的活性成分有更好的了解，它们可以成为局部治疗选择中有价值的补充。本综述探讨了两种具有成熟生产工艺和全球分销的著名天然物质——海洋来源的脂肪酸（包括其代谢物）和麦卢卡蜂蜜——它们作为抗菌剂的功能以及它们如何有助于伤口修复，这是导致慢性伤口愈合的两个重要方面。
