Clare Jenna, Lindley Martin R, Ratcliffe Elizabeth
Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, UK.
School of Health Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney 2052, Australia.
Microorganisms. 2024 Apr 11;12(4):778. doi: 10.3390/microorganisms12040778.
Both honey and fish oil have been historically used in medicine and identified as having antimicrobial properties. Although analyses of the substances have identified different components within them, it is not fully understood how these components interact and contribute to the observed effect. With the increase in multi-drug resistant strains of bacteria found in infections, new treatment options are needed. This study aimed to assess the antimicrobial abilities of fish oil components, including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and derived resolvins (RvE1, RvD2, and RvD3), as well as two varieties of manuka honey, against a panel of medically relevant microorganisms and antimicrobial resistant organisms, such as Methicillin Resistant (MRSA) and carbapenem-resistant . Minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were identified; further minimum biofilm eradication concentrations (MBEC) were investigated for responsive organisms, including , , , , and Concurrent with the existing literature, manuka honey was found to be a broad-spectrum antimicrobial with varied potency according to methylglyoxal content. DHA and EPA were both effective against Gram-positive and negative bacteria, but some drug-resistant strains or pathogens were not protected by a capsule. Only was inhibited by the resolvins.
蜂蜜和鱼油在历史上都曾被用于医学，并被认为具有抗菌特性。尽管对这些物质的分析已确定其内部含有不同成分，但人们尚未完全了解这些成分是如何相互作用并产生所观察到的效果的。随着感染中发现的多重耐药细菌菌株的增加，需要新的治疗选择。本研究旨在评估鱼油成分（包括二十二碳六烯酸（DHA）、二十碳五烯酸（EPA）和衍生的消退素（RvE1、RvD2和RvD3））以及两种麦卢卡蜂蜜对一组医学相关微生物和抗菌耐药菌（如耐甲氧西林金黄色葡萄球菌（MRSA）和耐碳青霉烯类菌）的抗菌能力。确定了最低抑菌浓度（MIC）和最低杀菌浓度（MBC）；针对包括……在内的敏感菌，进一步研究了最低生物膜清除浓度（MBEC）。与现有文献一致，发现麦卢卡蜂蜜是一种广谱抗菌剂，其效力因甲基乙二醛含量而异。DHA和EPA对革兰氏阳性菌和阴性菌均有效，但一些耐药菌株或病原体没有被荚膜保护。只有……被消退素抑制。
