Bajka Anahita, Said Sadiq, Quiblier Chantal, Schulthess Bettina, Reinhold Ilana, Barthelmes Daniel, Zweifel Sandrine Anne, Blaser Frank
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland.
Microorganisms. 2024 Aug 10;12(8):1637. doi: 10.3390/microorganisms12081637.
Fungal keratitis is a rare yet severe infection of the cornea. Fungal species distribution depends on the climate and socioeconomic status and can show regional variation. This retrospective single-center study was conducted at a tertiary eye care center and the collaborating Institute of Medical Microbiology in Switzerland. On investigating all fungal-positive corneal scrapings and contact lens assessments of patients with keratitis from January 2012 to December 2023, 206 patients were identified, of which 113 (54.9%) were female. The median age was 38 (IQR 29.8, [18-93]), and 154 (74.8%) applied contact lenses. The most commonly found pathogen was spp., followed by spp. Molds were 1.8 times more common than yeasts. Linear regression showed no significant increase or decrease in the infection rate over time ( = 0.5). In addition, 10 patients (4.9%) were found to have coinfections with , 11 (5.3%) with HSV-1, none with HSV-2, and 4 (1.9%) with VZV. This study provides a long-term overview of fungal-positive corneal scrapings and contact lens specimens of patients with fungal keratitis. Based on our results, coinfections with , HSV, and VZV are frequent, especially in patients wearing contact lenses. Thus, wearing contact lenses may facilitate coinfection in fungal keratitis.
真菌性角膜炎是一种罕见但严重的角膜感染。真菌种类分布取决于气候和社会经济状况，且可能存在地区差异。这项回顾性单中心研究在瑞士一家三级眼科护理中心以及合作的医学微生物学研究所开展。在调查2012年1月至2023年12月期间角膜炎患者的所有真菌阳性角膜刮片和隐形眼镜评估情况时，共确定了206例患者，其中113例（54.9%）为女性。年龄中位数为38岁（四分位间距29.8，范围[18 - 93]），154例（74.8%）使用隐形眼镜。最常发现的病原体是 属菌，其次是 属菌。霉菌比酵母菌常见1.8倍。线性回归显示感染率随时间无显著增加或降低（ = 0.5）。此外，发现10例患者（4.9%）合并感染 ，11例（5.3%）合并感染HSV - 1，无合并感染HSV - 2的病例，4例（1.9%）合并感染VZV。本研究提供了真菌性角膜炎患者真菌阳性角膜刮片和隐形眼镜标本的长期概况。根据我们的结果，合并感染 、HSV和VZV的情况很常见，尤其是在佩戴隐形眼镜的患者中。因此，佩戴隐形眼镜可能会促进真菌性角膜炎的合并感染。
