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在一家三级护理中心的角膜科就诊的感染性角膜炎患者中，阳性微生物培养结果。

Positive Microbiological Culture among Patients with Infective Keratitis Visiting the Cornea Unit of a Tertiary Care Centre.

机构信息

Department of Ophthalmology, Nepal Eye Hospital, Tripureshwor, Kathmandu, Nepal.

Department of Optometry, Nepal Eye Hospital, Tripureshwor, Kathmandu, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2023 Oct 1;61(266):775-778. doi: 10.31729/jnma.8285.

DOI:10.31729/jnma.8285
PMID:38289787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10579763/
Abstract

INTRODUCTION

Keratitis is the infection and inflammation of the cornea. Microbial keratitis is a potentially sight-threatening corneal condition. The aim of this study was to find out the prevalence of positive microbiological culture among patients with infective keratitis visiting the Cornea Unit of a tertiary care centre.

METHODS

A descriptive cross-sectional study was conducted among patients with a clinical diagnosis of infective keratitis presenting to the Cornea Unit of a tertiary eye care centre from 16 October 2020 to 16 March 2021 after obtaining ethical approval from the Ethical Review Board. After slit-lamp examination, corneal scrapings were performed under aseptic conditions which were subjected to Gram stain, potassium hydroxide preparation and culture for bacterial and fungal pathogens. A convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval.

RESULTS

Among 428 patients, 337 (78.73%) (73.24-84.33, 95% Confidence Interval) had a positive microbiological culture. A total of 213 (49.76%) of enrolled samples had a prior history of ocular trauma. Aspergillus species 68 (20.17%) and Streptococcus species 33 (9.79%) were the most common organisms isolated from fungal and bacterial corneal ulcers respectively.

CONCLUSIONS

The prevalence of positive microbiological culture among patients with infective keratitis from this study is similar to the pattern reported from similar settings.

KEYWORDS

corneal ulcer; keratitis; prevalence.

摘要

引言

角膜炎是角膜的感染和炎症。微生物角膜炎是一种潜在的威胁视力的角膜疾病。本研究旨在了解在一家三级护理中心的角膜科就诊的感染性角膜炎患者中，微生物培养阳性的患病率。

方法

在获得伦理审查委员会的伦理批准后，对 2020 年 10 月 16 日至 2021 年 3 月 16 日期间在一家三级眼科护理中心的角膜科就诊的临床诊断为感染性角膜炎的患者进行了一项描述性横断面研究。在裂隙灯检查后，在无菌条件下进行角膜刮片，将其进行革兰氏染色、氢氧化钾制备和细菌及真菌病原体培养。采用方便抽样法。点估计值是在 95%置信区间计算的。

结果

在 428 名患者中，337 名（78.73%）（73.24-84.33，95%置信区间）的微生物培养呈阳性。总共 213 名（49.76%）入组样本有眼部创伤史。从真菌和细菌性角膜溃疡中分别分离出的最常见的病原体是曲霉菌属 68 株（20.17%）和链球菌属 33 株（9.79%）。

结论

本研究中感染性角膜炎患者微生物培养阳性的患病率与类似环境下报告的模式相似。

关键词

角膜溃疡；角膜炎；流行率。