Koutsokostas Christos, Merkouris Ermis, Goulas Apostolos, Aidinopoulou Konstantina, Sini Niki, Dimaras Theofanis, Tsiptsios Dimitrios, Mueller Christoph, Nystazaki Maria, Tsamakis Konstantinos
Neurology Department, Democritus University of Thrace, 68100 Alexandroupoli, Greece.
3rd Neurology Department, Aristotle University, 54124 Thessaloniki, Greece.
Microorganisms. 2024 Aug 22;12(8):1735. doi: 10.3390/microorganisms12081735.
Evidence shows that neurodegenerative and neuropsychiatric disorders are influenced by alterations in the gut microbiome. Various diseases have been linked to microbiome dysbiosis, yet there are inconclusive data regarding which microorganisms are associated with each disorder. The aim of our study is to systematically review the recent literature of the past decade to clarify whether the gut microbiome contributes to the understanding of pathogenesis and progression of neurodegenerative disorders. Most included studies showed a strong correlation between the relative abundance of certain microorganisms, mainly species of the phyla and , and disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD). It is speculated that the microorganisms and their byproducts have a significant role in brain protein accumulation, neuro-inflammation, and gut permeability. The estimation of microbial populations could potentially improve clinical outcomes and hinder the progression of the disease. However, further research is needed to include more diseases and larger patient samples and identify specific species and subspecies associated with these disorders.
有证据表明，神经退行性疾病和神经精神疾病受肠道微生物群改变的影响。多种疾病已与微生物群失调相关联，但关于哪些微生物与每种疾病相关的数据尚无定论。我们研究的目的是系统回顾过去十年的近期文献，以阐明肠道微生物群是否有助于理解神经退行性疾病的发病机制和进展。大多数纳入研究表明，某些微生物的相对丰度，主要是门和门的物种，与帕金森病（PD）和阿尔茨海默病（AD）等疾病之间存在很强的相关性。据推测，这些微生物及其副产品在脑蛋白积累、神经炎症和肠道通透性方面具有重要作用。对微生物种群的评估可能会改善临床结果并阻碍疾病的进展。然而，需要进一步的研究纳入更多疾病和更大的患者样本，并确定与这些疾病相关的特定物种和亚种。
