Grupo USP-CEU de Excelencia "Nutrición para la Vida (Nutrition for Life)", Ref: E02/0720, Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain.
Instituto CEU Alimentación y Sociedad, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain.
Nutrients. 2024 Aug 9;16(16):2632. doi: 10.3390/nu16162632.
Hydration status plays a key role in healthy ageing, and it is potentially affected by several factors, including drug consumption. However, research on this issue to date is scarce, especially in highly vulnerable groups, such as the elderly. We aimed to study the relationship linking hydration status, analysed by means of a validated questionnaire, 24 h urine analysis, body composition assessment, and drug consumption in a sample of old adults. A total of 144 elders were included in the study. Cardiovascular drug consumption was significantly associated with a lower water intake in men ( = -0.282, = 0.029). Moreover, urinary analysis revealed that total drug intake as well as the consumption of diuretics and cardiovascular drugs were associated with poorer hydration status, whereas genito-urinary drugs were associated with an opposite effect, and these results were confirmed in terms of body composition. Hence, total drug consumption ( = -0.205), diuretic ( = -0.408), cardiovascular ( = -0.297), and genito-urinary drugs ( = 0.298) were significantly associated ( < 0.05) with total body water. The obtained results confirmed the impact of chronic treatment with certain drugs on hydration status. Nutritional interventions may be of great interest in certain population groups in order to prevent complications due to altered hydration status.
水合状态在健康老龄化中起着关键作用，它可能受到多种因素的影响，包括药物的使用。然而，迄今为止，关于这个问题的研究很少，特别是在老年人等高度脆弱的群体中。我们旨在研究通过一种经过验证的问卷、24 小时尿液分析、身体成分评估和药物使用来分析的水合状态与老年人样本之间的关系。共有 144 名老年人参与了这项研究。心血管药物的使用与男性的水摄入量减少（ = -0.282， = 0.029）显著相关。此外，尿液分析表明，总药物摄入量以及利尿剂和心血管药物的使用与较差的水合状态相关，而生殖泌尿系统药物则具有相反的效果，这些结果在身体成分方面得到了证实。因此，总药物使用量（ = -0.205）、利尿剂（ = -0.408）、心血管药物（ = -0.297）和生殖泌尿系统药物（ = 0.298）与总体水（TBW）呈显著相关（<0.05）。研究结果证实了某些药物的慢性治疗对水合状态的影响。营养干预可能对某些人群具有重要意义，以预防因水合状态改变而引起的并发症。
