Department of Human Studies, School of Education and Human Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Department of Kinesiology, School of Public Health, Indiana University, Bloomington, IN 47405, USA.
Nutrients. 2024 Aug 10;16(16):2636. doi: 10.3390/nu16162636.
Physical inactivity and poor dietary choices contribute to the rise in cardiometabolic diseases in the United States. It remains critical to identify strategies that may mitigate the negative impact of these behaviors. Several studies have shown that the consumption of dietary inorganic nitrate may improve vascular health and glucose regulation in animal models and some human studies. However, the improvements in glucose regulation have yet to be corroborated in humans with type 2 diabetes (T2D). Therefore, the purpose of this study was to assess the acute effects of beetroot juice (BRJ) on glycemic and hemodynamic responses in individuals with T2D while controlling for medication. Seven participants with a clinical diagnosis of T2D were recruited into this study and were temporarily removed from blood pressure- and glucose-lowering medications. Hemodynamic measurements (pulsewave velocity) and an oral glucose tolerance test (glycemic response) were measured following consumption of either BRJ or a denitrolized placebo. Saliva and blood samples were collected at baseline and two and four hours post supplementation to measure changes in nitrate and nitrite concentrations. We detected significant improvements in total plasma glucose exposure ( = 0.022) and the SVR change score ( = 0.009) in the BRJ condition. This study demonstrated that BRJ consumption can improve oral glucose tolerance in individuals with T2D while controlling for medication; however, future larger-cohort randomized controlled trials are needed to confirm if BRJ is a viable treatment for glucose control in individuals with T2D.
身体活动不足和不良的饮食选择导致美国心血管代谢疾病的发病率上升。因此，仍然需要确定可能减轻这些行为负面影响的策略。几项研究表明，饮食中无机硝酸盐的摄入可以改善动物模型和一些人体研究中的血管健康和葡萄糖调节。然而，在 2 型糖尿病 (T2D) 患者中，葡萄糖调节的改善尚未得到证实。因此，本研究的目的是评估甜菜根汁 (BRJ) 在控制药物的情况下对 T2D 个体血糖和血液动力学反应的急性影响。这项研究招募了 7 名临床诊断为 T2D 的参与者，并暂时停止服用降血压和降血糖药物。在饮用 BRJ 或脱硝化安慰剂后，测量血液动力学测量（脉搏波速度）和口服葡萄糖耐量试验（血糖反应）。在补充剂后两小时和四小时收集唾液和血液样本，以测量硝酸盐和亚硝酸盐浓度的变化。我们发现在 BRJ 条件下，总血浆葡萄糖暴露（=0.022）和 SVR 变化评分（=0.009）有显著改善。本研究表明，BRJ 摄入可以改善 T2D 个体的口服葡萄糖耐量，同时控制药物；然而，需要更大的队列随机对照试验来证实 BRJ 是否是 T2D 个体血糖控制的可行治疗方法。
