Department of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.
Nutrients. 2024 Aug 14;16(16):2692. doi: 10.3390/nu16162692.
Intermittent fasting has drawn significant interest in the clinical research community due to its potential to address metabolic complications such as obesity and type 2 diabetes mellitus. Various intermittent fasting regimens include alternate-day fasting (24 h of fasting followed by 24 h of eating), time-restricted fasting (fasting for 14 h and eating within a 10 h window), and the 5:2 diet (fasting for two days and eating normally for the other five days). Intermittent fasting is associated with a reduced risk of type 2 diabetes mellitus-related complications and can slow their progression. The increasing global prevalence of type 2 diabetes mellitus highlights the importance of early management. Since prediabetes is a precursor to type 2 diabetes mellitus, understanding its progression is essential. However, the long-term effects of intermittent fasting on prediabetes are not yet well understood. Therefore, this review aims to comprehensively compile existing knowledge on the therapeutic effects of intermittent fasting in managing type 2 diabetes mellitus and prediabetes.
间歇性禁食由于其在解决代谢并发症（如肥胖和 2 型糖尿病）方面的潜力，引起了临床研究界的极大关注。各种间歇性禁食方案包括隔日禁食（禁食 24 小时，然后进食 24 小时）、限时禁食（禁食 14 小时，在 10 小时窗口内进食）和 5:2 饮食法（禁食两天，其余五天正常进食）。间歇性禁食与降低 2 型糖尿病相关并发症的风险有关，并可减缓其进展。2 型糖尿病的全球患病率不断上升，凸显了早期管理的重要性。由于糖尿病前期是 2 型糖尿病的前兆，了解其进展至关重要。然而，间歇性禁食对糖尿病前期的长期影响尚不清楚。因此，本综述旨在全面汇编关于间歇性禁食在治疗 2 型糖尿病和糖尿病前期方面的治疗效果的现有知识。
