Tavakoli Atefeh, Bideshki Mohammad Vesal, Zamani Parastou, Tavakoli Fatemeh, Dehghan Parvin, Gargari Bahram Pourghassem
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry and Diet Therapy, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
J Health Popul Nutr. 2025 Apr 2;44(1):104. doi: 10.1186/s41043-025-00834-1.
A current investigation was performed to review and summarize the results of randomized clinical trials (RCTs) studies that have assessed the effectiveness of fasting regimens (FRs) including intermittent fasting (IF), time-restricted feeding (TRF), alternate day fasting (ADF) and fasting-mimicking diet (FMD) on some weight regulation hormones included; leptin, adiponectin, ghrelin, and resistin in healthy, overweight and obese adults recently. Four databases have been reviewed until June 2024 using keywords related to the subject of the study. Overall, 16 documents were considered in this study. Based on Pooled effect sizes, the FRs marginal significantly increased the level of adiponectin (weighted mean differences (WMD): 0.41 µg/ml, 95% confidence interval (CI): - 0.07 to 0.89, P: 0.09) and also significantly decreased the level of leptin (WMD: - 2.65 ng/ml, 95% CI: - 3.86 to - 1.44, p < 0.001) and ghrelin (WMD: - 0.57 ng/ml, 95% CI: - 1.01 to - 0.03, P: 0.01). There was no significant effect of this regimen approach on resistin levels. In general, according to this evaluation, FRs have a beneficial impact on weight-regulating hormone levels, still the long-term effects of these dietary approaches should also be evaluated in future studies.
目前进行了一项调查，以回顾和总结随机临床试验（RCT）的研究结果，这些研究评估了禁食方案（FRs）的有效性，包括间歇性禁食（IF）、限时进食（TRF）、隔日禁食（ADF）和禁食模拟饮食（FMD）对近期健康、超重和肥胖成年人的一些体重调节激素的影响，这些激素包括瘦素、脂联素、胃饥饿素和抵抗素。直到2024年6月，使用与该研究主题相关的关键词对四个数据库进行了检索。总体而言，本研究纳入了16篇文献。基于合并效应量，禁食方案显著提高了脂联素水平（加权平均差（WMD）：0.41µg/ml，95%置信区间（CI）：-0.07至0.89，P：0.09），同时显著降低了瘦素水平（WMD：-2.65ng/ml，95%CI：-3.86至-1.44，p<0.001）和胃饥饿素水平（WMD：-0.57ng/ml，95%CI：-1.01至-0.03，P：0.01）。该方案对抵抗素水平没有显著影响。总体而言，根据这项评估，禁食方案对体重调节激素水平有有益影响，但这些饮食方法的长期影响仍应在未来的研究中进行评估。
