Coronado Liani, Muñoz-Aguilera Adriana, Cantero Guillermo, Martínez Patricia, Alberch Mònica, Rosell Rosa, Gladue Douglas P, Borca Manuel V, Ganges Llilianne
WOAH Reference Laboratory for Classical Swine Fever, IRTA-CReSA, 08193 Barcelona, Spain.
Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Bellaterra, 08193 Barcelona, Spain.
Vaccines (Basel). 2024 Jul 23;12(8):832. doi: 10.3390/vaccines12080832.
The transplacental transmission of CSFV and the resulting persistent congenital infection in newborn piglets have been abundantly discussed in pregnant sows suffering from virus infection. Importantly, the availability of safe commercial vaccines with proven efficacy to prevent the generation of congenital and postnatal persistent infections in pregnant sows are critical tools for controlling the disease in CSF endemic areas. Here, we demonstrate the high efficacy of a single dose of the recombinant FlagT4G vaccine to provide solid protection in pregnant sows against transplacental transmission of a highly virulent CSFV. Pregnant sows vaccinated with FlagT4G at 44 days of gestation elicited a strong CSFV-specific antibody response, with neutralizing antibody levels above those required for protection against CSFV. Importantly, after the challenge with a highly virulent CSFV, all foetuses from FlagT4G-vaccinated sows lacked CSF macroscopic lesions and showed a complete absence of the challenge virus in their internal organs at day 79 of gestation. Therefore, pregnant sows safely vaccinated with FlagT4G without affecting reproductive efficacy are efficaciously protected, along with their foetuses, against the infection and disease caused by a CSFV virulent field strain.
猪瘟病毒（CSFV）的经胎盘传播以及由此导致新生仔猪持续性先天性感染，在感染病毒的怀孕母猪中已被广泛讨论。重要的是，拥有经证实有效的安全商业疫苗，以预防怀孕母猪发生先天性和产后持续性感染，是在CSF流行地区控制该病的关键工具。在此，我们证明单剂量重组FlagT4G疫苗在保护怀孕母猪免受高致病性CSFV经胎盘传播方面具有高效性。在妊娠44天时用FlagT4G疫苗接种的怀孕母猪产生了强烈的CSFV特异性抗体反应，中和抗体水平高于预防CSFV所需的水平。重要的是，在用高致病性CSFV攻击后，在妊娠79天时，来自接种FlagT4G疫苗母猪的所有胎儿均无CSF宏观病变，且其内脏器官完全没有攻击病毒。因此，安全接种FlagT4G疫苗且不影响繁殖效力的怀孕母猪及其胎儿能有效抵御CSFV强毒田间毒株引起的感染和疾病。
