Fikry Eman, Orfali Raha, Tawfeek Nora, Perveen Shagufta, Ghafar Safina, El-Domiaty Maher M, El-Shafae Azza M
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Department of Pharmacognosy, Collage of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Pharmaceuticals (Basel). 2024 Aug 2;17(8):1019. doi: 10.3390/ph17081019.
Prior studies have extensively investigated the essential oil derived from the Mediterranean cypress, . However, the 'Stricta' variety, known for its ornamental value, has received less attention in terms of its oil composition and potential health benefits. The objective of this research was to comprehensively analyze the chemical components and medicinal properties of the essential oil extracted from 'Stricta' (CSSLEO) grown in Egypt. Utilizing gas chromatography-mass spectrometry (GC-MS), the investigation identified 22 compounds within CSSLEO, with -pinene and -3-carene being predominant, accounting for 96.01% of the oil. In vitro assays evaluated CSSLEO's cytotoxic effects on cancer cell lines, revealing notable anticancer potential. Additionally, the oil displayed antidiabetic properties by impeding crucial enzymes involved in glucose metabolism. Complementary in silico network pharmacology and molecular docking studies provided insights into the possible interactions between CSSLEO's key compounds and essential proteins and pathways in cancer treatment. The results underscored CSSLEO's intricate composition and its promising applications in cancer prevention and diabetes management. The conclusions drawn from this research underscore the need for further investigation to validate CSSLEO's clinical effectiveness and to gain a deeper understanding of its therapeutic mechanisms, with a view to harnessing its potential in oncology and endocrinology.
先前的研究已经广泛调查了源自地中海柏木的精油。然而，以其观赏价值而闻名的“Stricta”品种，在其油的成分和潜在健康益处方面受到的关注较少。本研究的目的是全面分析从埃及种植的“Stricta”（CSSLEO）中提取的精油的化学成分和药用特性。利用气相色谱 - 质谱联用（GC - MS），该调查在CSSLEO中鉴定出22种化合物，其中α - 蒎烯和β - 3 - 蒈烯占主导地位，占该油的96.01%。体外试验评估了CSSLEO对癌细胞系的细胞毒性作用，揭示了显著的抗癌潜力。此外，该油通过阻碍参与葡萄糖代谢的关键酶而表现出抗糖尿病特性。互补的计算机网络药理学和分子对接研究为CSSLEO的关键化合物与癌症治疗中的必需蛋白质和途径之间的可能相互作用提供了见解。结果强调了CSSLEO复杂的成分及其在癌症预防和糖尿病管理中的应用前景。本研究得出的结论强调需要进一步研究以验证CSSLEO的临床有效性，并更深入地了解其治疗机制，以期利用其在肿瘤学和内分泌学中的潜力。
