Herdiana Yedi, Febrina Ellin, Nurhasanah Siti, Gozali Dolih, Elamin Khaled M, Wathoni Nasrul
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia.
Pharmaceutics. 2024 Aug 6;16(8):1043. doi: 10.3390/pharmaceutics16081043.
Chitosan nanoparticles (CSNPs) are promising vehicles for targeted and controlled drug release. Recognized for their biodegradability, biocompatibility, low toxicity, and ease of production, CSNPs represent an effective approach to drug delivery. Encapsulating drugs within nanoparticles (NPs) provides numerous benefits compared to free drugs, such as increased bioavailability, minimized toxic side effects, improved delivery, and the incorporation of additional features like controlled release, imaging agents, targeted delivery, and combination therapies with multiple drugs. Keys parameters in nanomedicines are drug loading content and drug loading efficiency. Most current NP systems struggle with low drug loading, presenting a significant challenge to the field. This review summarizes recent research on developing CSNPs with high drug loading capacity, focusing on various synthesis strategies. It examines CSNP systems using different materials and drugs, providing details on their synthesis methods, drug loadings, encapsulation efficiencies, release profiles, stability, and applications in drug delivery. Additionally, the review discusses factors affecting drug loading, providing valuable guidelines for future CSNPs' development.
壳聚糖纳米粒（CSNPs）是用于靶向和控释药物的有前景的载体。CSNPs因其生物可降解性、生物相容性、低毒性和易于生产而受到认可，是一种有效的药物递送方法。与游离药物相比，将药物封装在纳米粒（NPs）中具有诸多益处，如提高生物利用度、将毒副作用降至最低、改善递送效果，以及加入控释、成像剂、靶向递送和多种药物联合治疗等附加特性。纳米药物中的关键参数是载药量和载药效率。目前大多数纳米粒系统都存在载药量低的问题，这给该领域带来了重大挑战。本综述总结了近期关于开发高载药量CSNPs的研究，重点关注各种合成策略。它研究了使用不同材料和药物的CSNP系统，详细介绍了它们的合成方法、载药量、包封效率、释放曲线、稳定性以及在药物递送中的应用。此外，该综述还讨论了影响载药的因素，为未来CSNPs的发展提供了有价值的指导方针。
