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环糊精及其衍生物在纳米递送系统中的研究进展

Advances in Cyclodextrins and Their Derivatives in Nano-Delivery Systems.

作者信息

Ji Xin-Yu, Zou Yi-Xuan, Lei Han-Fang, Bi Yong, Yang Rui, Tang Ji-Hui, Jin Qing-Ri

机构信息

School of Pharmacy, Hangzhou Medical College, Hangzhou 310053, China.

National institute of Metrology, Beijing 100029, China.

出版信息

Pharmaceutics. 2024 Aug 9;16(8):1054. doi: 10.3390/pharmaceutics16081054.

DOI:10.3390/pharmaceutics16081054
PMID:39204399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11360519/
Abstract

The diversity of cyclodextrins and their derivatives is increasing with continuous research. In addition to monomolecular cyclodextrins with different branched chains, cyclodextrin-based polymers have emerged. The aim of this review is to summarize these innovations, with a special focus on the study of applications of cyclodextrins and their derivatives in nano-delivery systems. The areas covered include nanospheres, nano-sponges, nanogels, cyclodextrin metal-organic frameworks, liposomes, and emulsions, providing a comprehensive and in-depth understanding of the design and development of nano-delivery systems.

摘要

随着持续的研究,环糊精及其衍生物的多样性正在增加。除了具有不同支链的单分子环糊精外,基于环糊精的聚合物也已出现。本综述的目的是总结这些创新,特别关注环糊精及其衍生物在纳米递送系统中的应用研究。涵盖的领域包括纳米球、纳米海绵、纳米凝胶、环糊精金属有机框架、脂质体和乳液,从而对纳米递送系统的设计与开发提供全面而深入的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/209b/11360519/0ea68f4c6dd3/pharmaceutics-16-01054-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/209b/11360519/0ea68f4c6dd3/pharmaceutics-16-01054-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/209b/11360519/0ea68f4c6dd3/pharmaceutics-16-01054-g001.jpg

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Biomacromolecules. 2024 May 13;25(5):2980-2989. doi: 10.1021/acs.biomac.4c00123. Epub 2024 Apr 8.
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Chitosan and Cyclodextrins-Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers.壳聚糖与环糊精——用于创建胃肠道癌症药物递送系统的多功能材料
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Supramolecular nanomedicines based on host-guest interactions of cyclodextrins.基于环糊精主客体相互作用的超分子纳米药物。
Exploration (Beijing). 2023 May 28;3(4):20210111. doi: 10.1002/EXP.20210111. eCollection 2023 Aug.
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