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慢性 HIV 感染患者的现代抗逆转录病毒治疗方案与免疫衰老标志物之间的关系。

Relationship between Modern ART Regimens and Immunosenescence Markers in Patients with Chronic HIV Infection.

机构信息

Department of Infectious Diseases, Parasitology and Tropical Medicine, Medical University Sofia, 1431 Sofia, Bulgaria.

Central Laboratory of Clinical Immunology, University Hospital Alexandrovska, 1431 Sofia, Bulgaria.

出版信息

Viruses. 2024 Jul 26;16(8):1205. doi: 10.3390/v16081205.

DOI:10.3390/v16081205
PMID:39205179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11360605/
Abstract

The increased life expectancy of PLHIV (People Living with HIV) and the successful highly combined antiretroviral therapy (cART) poses new clinical challenges regarding aging and its co-morbid condition. It is commonly believed that HIV infection "accelerates" aging. Human immunodeficiency virus type 1 (HIV-1) infection is characterized by inflammation and immune activation that persists despite cART, and that may contribute to the development of co-morbid conditions. In this regard, we aimed to compare current cART regimens in light of premature aging to evaluate differences in their ability to reduce immune activation and inflammation in virologically suppressed patients. We studied a panel of biomarkers (IFN-γ, IL-1β, IL-12p70, IL-2, IL-4, IL-5, IL-6, IL-13, IL-18, GM-CSF, TNF-α, C-reactive protein, D-dimer, soluble CD14), which could provide a non-invasive and affordable approach to monitor HIV-related chronic inflammation. The results of the current study do not provide hard evidence favoring a particular cART regimen, although they show a less favorable regimen profile containing a protease inhibitor. Our data suggest an incomplete reduction of inflammation and immune activation in terms of the effective cART. It is likely that the interest in various biomarkers related to immune activation and inflammation as predictors of clinical outcomes among PLHIV will increase in the future.

摘要

随着 HIV 感染者（PLHIV）预期寿命的延长和高效联合抗逆转录病毒治疗（cART）的成功，与衰老及其合并症相关的新临床挑战随之而来。人们普遍认为 HIV 感染“加速”了衰老。人类免疫缺陷病毒 1 型（HIV-1）感染的特征是炎症和免疫激活持续存在，尽管进行了 cART，但仍可能导致合并症的发生。在这方面，我们旨在根据过早衰老来比较当前的 cART 方案，以评估它们降低病毒抑制患者免疫激活和炎症的能力差异。我们研究了一组生物标志物（IFN-γ、IL-1β、IL-12p70、IL-2、IL-4、IL-5、IL-6、IL-13、IL-18、GM-CSF、TNF-α、C 反应蛋白、D-二聚体、可溶性 CD14），这些标志物可以提供一种非侵入性且经济实惠的方法来监测与 HIV 相关的慢性炎症。尽管目前的研究结果并未提供有利于特定 cART 方案的确凿证据，但它们显示出含有蛋白酶抑制剂的方案具有较差的特征。我们的数据表明，就有效的 cART 而言，炎症和免疫激活的减少并不完全。未来，人们可能会对与免疫激活和炎症相关的各种生物标志物作为 PLHIV 临床结局的预测指标产生更大的兴趣。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b1/11360605/f8d98fa5b67d/viruses-16-01205-g006.jpg
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