Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center, U1153 National Institute of Health and Medical Research (INSERM), U1125 National Institute for Agricultural Research (INRA), National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Sorbonne Paris Cité COMUE, F-93017 Bobigny, France.
AP-HP, Diagnosis and Therapeutic Center, Faculty of Medicine, Hôtel-Dieu Hospital, Paris-Descartes University, F-75004 Paris, France.
Nutrients. 2018 Jun 30;10(7):854. doi: 10.3390/nu10070854.
With increasing life expectancies worldwide, it is an important public health issue to identify factors that influence the quality of aging. We aimed to investigate the individual and combined roles of lifestyle factors at midlife for healthy aging (HA). We analyzed data from 2203 participants of the French ”Supplémentation en Vitamines et Minéraux Antioxydants” (SU.VI.MAX) cohort aged 45⁻60 years at baseline (1994⁻1995), and assessed the combined impact of lifestyle factors (weight, smoking status, physical activity, alcohol consumption, and diet) on HA (absence of chronic diseases and function-limiting pain, good physical and cognitive functioning, functional independence, no depressive symptoms, and good social and self-perceived health) with a five-component healthy lifestyle index (HLI). Relative risks (RR) and 95% confidence intervals (CIs) were estimated using a robust-error-variance Poisson regression. Approximately 39% of our sample aged healthily. After adjustment for potential confounders, a one-point increase in HLI was related to an 11% higher probability of HA (95% CI = 6%, 16%; < 0.001). The proportions of HA attributable to specific factors based on the “population attributable risk” concept were 7.6%, 6.0%, 7.8%, and 16.5% for body mass index (BMI), physical activity, diet quality, and smoking status, respectively. This study highlights the importance of healthy lifestyle habits at midlife for the promotion of good overall health during aging.
随着全球预期寿命的延长，确定影响衰老质量的因素是一个重要的公共卫生问题。我们旨在研究中年生活方式因素对健康衰老 (HA) 的个体和综合作用。我们分析了法国“补充抗氧化维生素和矿物质” (SU.VI.MAX) 队列中 2203 名年龄在 45⁻60 岁的参与者的数据，这些参与者在基线时（1994⁻1995 年）接受了评估，评估了生活方式因素（体重、吸烟状况、身体活动、饮酒和饮食）对 HA（无慢性疾病和功能受限性疼痛、良好的身体和认知功能、功能独立性、无抑郁症状以及良好的社会和自我感知健康）的综合影响，使用了一个由五个组成部分的健康生活方式指数 (HLI)。使用稳健误差方差泊松回归估计相对风险 (RR) 和 95%置信区间 (CI)。我们样本中约有 39%的人健康老龄化。在调整了潜在混杂因素后，HLI 增加一个点与 HA 的可能性增加 11%（95%CI=6%，16%；<0.001）相关。根据“人群归因风险”概念，特定因素归因于 HA 的比例分别为体重指数 (BMI)、身体活动、饮食质量和吸烟状况的 7.6%、6.0%、7.8%和 16.5%。这项研究强调了中年时期健康生活方式习惯对促进衰老期间整体健康的重要性。
