Department of Medical Laser, Graduate School of Medicine, Dankook University, Cheonan-si 31116, Republic of Korea.
Department of Biomedical Laboratory Science, College of Health Sciences, Dankook University, Cheonan-si 31116, Republic of Korea.
Viruses. 2024 Aug 20;16(8):1329. doi: 10.3390/v16081329.
This study investigated the potential associations between hepatitis virus antibody status and thyroid and inflammatory function. The C-reactive protein (CRP), thyroid-stimulating hormone (TSH), and free thyroxine (FT4) levels were measured in individuals with and without antibodies to the hepatitis A virus (HAV) and hepatitis B virus (HBV). Participants were stratified by age, sex, and HAV/HBV antibody status. Participants with and without antibodies to HAV and HBV had normal CRP, TSH, and FT4 levels. However, notable discrepancies were observed in FT4 levels among participants with HAV antibodies and in CRP and FT4 levels among those with both HAV and HBV antibodies, suggesting potential associations between viral immunity and thyroid function, especially in younger participants. Significant variations in thyroid hormone levels were noted when the sample was stratified by sex and HAV and HBV antibody status, indicating that the association between antibody status and thyroid hormone levels varied by sex. This study underscores the need for further research on the effect of viral immunity on inflammatory parameters and thyroid hormone levels.
本研究旨在探讨肝炎病毒抗体状态与甲状腺和炎症功能之间的潜在关联。在有和没有甲型肝炎病毒 (HAV) 和乙型肝炎病毒 (HBV) 抗体的个体中测量了 C 反应蛋白 (CRP)、促甲状腺激素 (TSH) 和游离甲状腺素 (FT4) 水平。参与者按年龄、性别和 HAV/HBV 抗体状态分层。有和没有 HAV 和 HBV 抗体的参与者的 CRP、TSH 和 FT4 水平正常。然而，在有 HAV 抗体的参与者中观察到 FT4 水平存在显著差异，在同时有 HAV 和 HBV 抗体的参与者中观察到 CRP 和 FT4 水平存在显著差异，表明病毒免疫与甲状腺功能之间存在潜在关联，尤其是在年轻参与者中。当按性别和 HAV 和 HBV 抗体状态对样本进行分层时，甲状腺激素水平存在显著差异，表明抗体状态与甲状腺激素水平之间的关联因性别而异。本研究强调了进一步研究病毒免疫对炎症参数和甲状腺激素水平的影响的必要性。
