Sultangazi Haseki Training and Research Hospital, Department of Otorhinolaryngology and Head and Neck Surgery, Istanbul, Turkey.
Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Otorhinolaryngology and Head and Neck Surgery, Istanbul, Turkey.
Braz J Otorhinolaryngol. 2024 Nov-Dec;90(6):101492. doi: 10.1016/j.bjorl.2024.101492. Epub 2024 Aug 10.
This study aims to assess the impact of the Neutrophil/Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP), both markers of systemic inflammation, on the duration of hospitalization for Deep Neck Infections (DNIs).
The research encompassed patients of all age groups admitted between January 2016 and January 2021 due to DNIs. Patient data, including demographic details, etiology, comorbidities, radiological findings, treatment specifics, laboratory results (CRP values, leukocyte counts, neutrophil counts, lymphocyte counts, NLR), culture outcomes, length of stay, complications, mortalities were retrospectively evaluated. Patients were categorized into two groups based on their hospitalization duration: less than 7-days and 7-days or more. Univariate and multivariate analyses were conducted to examine the association between age, NLR, CRP, and hospital stay length.
The study encompassed 275 patients, with a mean age of 36 ± 20.2 years. The mean hospital stay was 9.6 ± 6.6 days. Tonsillopharyngeal infections were the most common etiology (34%). Notably, in both univariate and multivariate analyses, age, NLR, and CRP values demonstrated significant (p < 0.05) predictive influence on hospitalization duration.
Age emerges as a determinant that affects hospital stay duration in DNIs. Moreover, NLR is proven to be comparable to CRP in predicting hospitalization length for these patients. NLR's feasibility as a cost-effective predictive marker, being conveniently derived from routine complete blood count assessments, adds to its clinical significance. This study underscores the potential value of NLR and CRP in informing patient management and care strategies for DNIs.
本研究旨在评估中性粒细胞/淋巴细胞比值（NLR）和 C 反应蛋白（CRP）这两个全身炎症标志物对深颈部感染（DNI）住院时间的影响。
研究纳入了 2016 年 1 月至 2021 年 1 月因 DNI 住院的所有年龄段的患者。回顾性评估患者数据，包括人口统计学细节、病因、合并症、影像学发现、治疗细节、实验室结果（CRP 值、白细胞计数、中性粒细胞计数、淋巴细胞计数、NLR）、培养结果、住院时间、并发症、死亡率。根据住院时间将患者分为两组：少于 7 天和 7 天或以上。进行单变量和多变量分析，以检查年龄、NLR、CRP 与住院时间长度之间的关联。
本研究纳入了 275 例患者，平均年龄为 36±20.2 岁。平均住院时间为 9.6±6.6 天。扁桃体咽感染是最常见的病因（34%）。值得注意的是，在单变量和多变量分析中，年龄、NLR 和 CRP 值均对住院时间有显著（p<0.05）的预测影响。
年龄是影响 DNI 住院时间的决定因素。此外，NLR 在预测这些患者的住院时间方面与 CRP 相当。NLR 作为一种具有成本效益的预测标志物的可行性，因为它可以从常规的全血细胞计数评估中方便地得出，增加了其临床意义。本研究强调了 NLR 和 CRP 在为 DNI 患者提供管理和护理策略方面的潜在价值。
