Du Peiyu, Zong Shimin, Wen Yingying, Liu Tianyi, Qu Yanji, Li Hao, Yu Wenting, Wang Enhao, Zhong Yi, Xiao Hongjun
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Int J Pediatr Otorhinolaryngol. 2020 Aug;135:110091. doi: 10.1016/j.ijporl.2020.110091. Epub 2020 May 8.
Studies have shown that Helicobacter pylori (H. pylori) infection may be associated with the occurrence of otitis media with effusion (OME) in children.
This is a systematic review of the relevant published literature to explore the relationship between H. pylori infection and OME in children.
Articles published before October 30, 2019 in the PubMed, Web of Science, Ovid, the China National Knowledge Infrastructure (CNKI) database, and Wanfang databases were retrieved. Articles were screened based on prespecified inclusion and exclusion criteria. Quality assessment was applied to the included studies. Data in the included studies were extracted and classified for qualitative analysis.
Ten studies, which enrolled a total of 397 cases and 334 controls, were included; all were case-control studies of varying quality. We summarized and compared H. pylori infections in different specimens from pediatric patients with OME. Due to the apparent heterogeneity between the included studies, meta-analysis was not appropriate, hence we carried out only a qualitative analysis.
The detection rate of H. pylori in the middle ear, tonsil and gastric juice in children with OME was higher than that in children without OME. There is no clear and reliable conclusion as to whether there is a difference in the detection rate of H. pylori in adenoid specimens of children with or without OME. Eradication of H. pylori may improve symptoms of drug-resistant OME. Nevertheless, more studies of higher quality are needed to improve the conclusions.
研究表明，幽门螺杆菌（H. pylori）感染可能与儿童分泌性中耳炎（OME）的发生有关。
对相关已发表文献进行系统综述，以探讨H. pylori感染与儿童OME之间的关系。
检索截至2019年10月30日在PubMed、Web of Science、Ovid、中国知网（CNKI）数据库和万方数据库发表的文章。根据预先设定的纳入和排除标准筛选文章。对纳入研究进行质量评估。提取纳入研究中的数据并进行分类以进行定性分析。
纳入10项研究，共纳入397例病例和334例对照；均为质量各异的病例对照研究。我们总结并比较了OME患儿不同标本中的H. pylori感染情况。由于纳入研究之间存在明显异质性，不适合进行荟萃分析，因此我们仅进行了定性分析。
OME患儿中耳、扁桃体和胃液中幽门螺杆菌的检出率高于无OME的儿童。对于有或无OME的儿童腺样体标本中幽门螺杆菌的检出率是否存在差异，尚无明确可靠的结论。根除幽门螺杆菌可能改善耐药性OME的症状。然而，需要更多高质量的研究来完善结论。
