State Key Laboratory of Natural Medicines, Department of Pharmaceutics and Pharmaceutical Engineering, China Pharmaceutical University (Nanjing), No. 24 Tongjia Rd., Nanjing, 211198, China.
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing), No. 30 South Puzhu Rd., Nanjing, 211816, China.
Adv Mater. 2024 Oct;36(40):e2406618. doi: 10.1002/adma.202406618. Epub 2024 Aug 29.
Stimuli-responsive ultralong organic phosphorescence (UOP) materials that in response to external factors such as light, heat, and atmosphere have raised a tremendous research interest in fields of optoelectronics, anticounterfeiting labeling, biosensing, and bioimaging. However, for practical applications in life and health fields, some fundamental requirements such as biocompatibility and biodegradability are still challenging for conventional inorganic and aromatic-based stimuli-responsive UOP systems. Herein, an edible excipient, sodium carboxymethyl cellulose (SCC), of which UOP properties exhibit intrinsically multistimuli responses to excited wavelength, pressure, and moisture, is reported. Impressively, as a UOP probe, SCC enables nondestructive detection of hardness with superb contrast (signal-to-background ratio up to 120), while exhibiting a response sensitivity to moisture that is more than 5.0 times higher than that observed in conventional fluorescence. Additionally, its applicability for hardness monitoring and high-moisture warning for tablets containing a moisture-sensitive drug, with the quality of the drug being determinable through the naked-eye visible UOP, is demonstrated. This work not only elucidates the reason for stimulative corresponding properties in SCC but also makes a major step forward in extending the potential applications of stimuli-responsive UOP materials in manufacturing high-quality and safe medicine.
对光、热和气氛等外部因素做出响应的刺激响应型超长有机磷光 (UOP) 材料，在光电、防伪标签、生物传感和生物成像等领域引起了极大的研究兴趣。然而，对于生命和健康领域的实际应用，一些基本要求，如生物相容性和可生物降解性，对于传统的无机和基于芳香族的刺激响应型 UOP 系统来说仍然具有挑战性。本文报道了一种可食用的赋形剂——羧甲基纤维素钠 (SCC)，其 UOP 性能对激发波长、压力和水分表现出固有多刺激响应。令人印象深刻的是，作为 UOP 探针，SCC 能够实现对硬度的无损检测，具有极好的对比度（信号与背景比高达 120），同时对水分的响应灵敏度比传统荧光高 5.0 倍以上。此外，它还可用于监测片剂的硬度和高湿度预警，其中含有水分敏感药物，通过肉眼可见的 UOP 可以确定药物的质量。这项工作不仅阐明了 SCC 中刺激对应性能的原因，而且在扩展刺激响应型 UOP 材料在制造高质量和安全药物方面的潜在应用方面迈出了重要一步。
