Department of Community Health, Faculty of Public Health, Mahidol University, Bangkok, Thailand.
The Excellence Center for DACH, Department of Community Public Health, School of Public Health, Walailak University, Nakhon Si Thammarat, Thailand.
Asian Pac J Cancer Prev. 2024 Aug 1;25(8):2679-2684. doi: 10.31557/APJCP.2024.25.8.2679.
Opisthorchis viverrini (OV) is a significant public health problem in Thailand, and OV reinfection poses a serious risk of cholangiocarcinoma with little evidence of a decrease. While numerous studies have explored OV reinfection and prevalence, most have been limited to short study period. Therefore, there is a need for long-term investigations to gather sufficient evidence.
This study aimed to access the current status of re-infection rates in high- risk areas and to determine associations between factors of and re-infection of OV at 5 years after treatment with praziquantel.
In total, this study included 457 participants from a cohort study. Each participant was required to answer a questionnaire and undergo stool examination using the formalin ethyl acetate concentration technique. Data were analyzed using descriptive statistics and multiple logistic regression.
Out of the total 457 participants, 418 (91.5%) successfully completed the questionnaires and underwent stool examinations. Among the participants, 10.8% showed re-infection with OV. Using multivariate analysis, factors significantly associated with reinfection OV included yearly income (OR adj = 2.14, 95%CI = 1.11- 4.12, p-value = 0.022) and past stool examination five years (OR adj = 2.47, 95%CI = 1.13-5.43, p-value = 0.023), respectively.
Subjects who frequently experience OV reinfection should undergo CCA screening by experts while closely monitoring their raw fish consumption behavior. Moreover, it is essential to implement comprehensive programs aimed at promoting behavioral changes and provide preventive education, with a specific focus on high epidemic areas, to discourage the consumption of raw fish.
肝吸虫（OV）是泰国的一个重大公共卫生问题，而 OV 再感染是导致胆管癌的严重风险因素，且鲜有证据表明其再感染率有所下降。虽然有许多研究探讨了 OV 的再感染和流行情况，但大多数研究的研究期都比较短。因此，需要进行长期调查以收集足够的证据。
本研究旨在评估高危地区的再感染率现状，并确定在吡喹酮治疗 5 年后 OV 再感染与相关因素之间的关联。
本研究共纳入了来自队列研究的 457 名参与者。每个参与者都需要回答一份问卷并接受粪便检查，采用甲醛-乙醚沉淀集卵法。使用描述性统计和多因素逻辑回归进行数据分析。
在总共 457 名参与者中，有 418 名（91.5%）成功完成了问卷调查和粪便检查。在这些参与者中，有 10.8%出现了 OV 再感染。使用多因素分析，与 OV 再感染显著相关的因素包括年收入（调整后的 OR=2.14，95%CI=1.11-4.12，p 值=0.022）和过去五年的粪便检查史（调整后的 OR=2.47，95%CI=1.13-5.43，p 值=0.023）。
频繁发生 OV 再感染的人群应由专家进行 CCA 筛查，并密切监测其生鱼食用行为。此外，实施旨在促进行为改变的综合计划以及提供预防性教育至关重要，特别是在高发地区，以劝阻生鱼的食用。
