Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, China.
Center of Vaccine Clinical Evaluation, Institute for Immunization Program, Shaanxi Provincial Centre for Disease Control and Prevention, Xi'an, Shaanxi Province, China.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2380111. doi: 10.1080/21645515.2024.2380111. Epub 2024 Aug 29.
Seasonal influenza is a severe disease that significantly impacts public health, causing millions of infections and hundreds of thousands of deaths each year. Seasonal influenza viruses, particularly the H3N2 subtype, exhibit high antigenic variability, often leading to mismatch between vaccine strains and circulating strains. Therefore, rapidly assessing the alignment between existing seasonal influenza vaccine and circulating strains is crucial for enhancing vaccine efficacy. This study, based on a pseudovirus platform, evaluated the match between current influenza H3N2 vaccine strains and circulating strains through cross-neutralization assays using clinical human immune sera against globally circulating influenza virus strains. The research results show that although mutations are present in the circulating strains, the current H3N2 vaccine strain still imparting effective protection, providing a scientific basis for encouraging influenza vaccination. This research methodology can be sustainably applied for the neutralization potency assessment of subsequent circulating strains, establishing a persistent methodological framework.
季节性流感是一种严重的疾病，对公众健康造成重大影响，每年导致数百万人感染和数十万人死亡。季节性流感病毒，特别是 H3N2 亚型，表现出高度的抗原变异性，经常导致疫苗株与流行株之间不匹配。因此，快速评估现有季节性流感疫苗与流行株之间的吻合程度对于提高疫苗的效果至关重要。本研究基于假病毒平台，通过使用针对全球流行流感病毒株的临床人类免疫血清进行的交叉中和试验，评估了当前流感 H3N2 疫苗株与流行株之间的匹配程度。研究结果表明，尽管流行株存在突变，但当前的 H3N2 疫苗株仍能提供有效保护，为鼓励流感疫苗接种提供了科学依据。这种研究方法可以可持续地应用于后续流行株的中和效力评估，建立一个持久的方法学框架。
