Shyu Miin-Yaw, Lee Andrew Ying-Siu
Department of Cardiology, Jen-Ai Hospital, Taichung, Taiwan, Republic of China.
Cardiol Res. 2024 Aug;15(4):309-313. doi: 10.14740/cr1669. Epub 2024 Jul 18.
Recently, it has been shown that remote ischemic conditioning (RIC) can be used as a healthy regimen to reverse disease and aging. With this in mind, we are studying the consequences of RIC on cardiovascular function in heart failure patients.
Forty patients with stable heart failure were prospectively enlisted and randomly divided into RIC (n = 20) and control (n = 20) groups. The RIC protocol consists of a 3-min inflation and then deflation of the blood pressure cuff attached to the upper arm to produce transient ischemia of the arm. RIC treatment was performed once daily for 1 year. NYHA class, left ventricular ejection fraction (LVEF), left atrial and ventricular dimensions were all assessed in two groups.
RIC was well tolerated. After 1 year of treatment, New York Heart Association (NYHA) class improved and LVEF showed a significant increase from 37.11% to 52.44% (P < 0.0001). Additionally, the dimensions of the left atrium (from 50.55 to 43.25 mm) and ventricle (from 53.04 to 50.15 mm) were significantly reduced in the RIC group.
This study suggests that 1 year of RIC treatment as a health strategy could improve cardiovascular function in heart failure patients, leading to its widespread use in these patients.
最近的研究表明，远程缺血预处理（RIC）可用作逆转疾病和衰老的健康方案。考虑到这一点，我们正在研究RIC对心力衰竭患者心血管功能的影响。
前瞻性招募40例稳定型心力衰竭患者，并随机分为RIC组（n = 20）和对照组（n = 20）。RIC方案包括将连接在上臂的血压袖带充气3分钟，然后放气，以产生手臂的短暂缺血。RIC治疗每天进行1次，持续1年。对两组患者均评估纽约心脏协会（NYHA）心功能分级、左心室射血分数（LVEF）、左心房和心室大小。
RIC耐受性良好。治疗1年后，纽约心脏协会（NYHA）心功能分级改善，LVEF显著提高，从37.11%升至52.44%（P < 0.0001）。此外，RIC组的左心房大小（从50.55 mm降至43.25 mm）和心室大小（从53.04 mm降至50.15 mm）显著减小。
本研究表明，作为一种健康策略，1年的RIC治疗可改善心力衰竭患者的心血管功能，从而使其在这些患者中得到广泛应用。
