Mitema E S, Kocan A A, Mukolwe S W, Sangiah S, Sherban D
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078.
Vet Parasitol. 1991 Jan;38(1):49-53. doi: 10.1016/0304-4017(91)90007-i.
Buparvaquone, a naphthoquinone with known efficacy against Theileria parva parva in cattle, was tested for activity against Theileria cervi piroplasms in both an in vitro culture system and in vivo in experimentally infected white-tailed deer. The in vitro data showed a significant decrease in the incorporation of 3H-hypoxanthine by infected red blood cells treated with buparvaquone when compared to that seen with imidocarb and chloroquine treatment. In both intact and splenectomized deer treated with buparvaquone (2.5 mg kg-1) a gradual decrease in piroplasm parasitaemia was observed following treatment. However, in the splenectomized deer, parasitaemia levels returned to near pretreatment values after approximately 2 weeks.
布帕喹酮是一种已知对牛的小泰勒虫有疗效的萘醌，在体外培养系统和实验感染的白尾鹿体内测试了其对鹿泰勒虫梨形虫的活性。体外数据显示，与咪唑苯脲和氯喹治疗相比，用布帕喹酮处理的感染红细胞对3H-次黄嘌呤的摄取显著减少。在用布帕喹酮（2.5 mg kg-1）治疗的完整和脾切除的鹿中，治疗后均观察到梨形虫血症逐渐降低。然而，在脾切除的鹿中，约2周后虫血症水平恢复到接近治疗前的值。
