Boehm P, Cooper K, Hudson A T, Elphick J P, McHardy N
J Med Chem. 1981 Mar;24(3):295-9. doi: 10.1021/jm00135a011.
A variety of naphthoquinones have veen prepared and evaluated in vitro against the causative agent of the cattle disease East Coast Fever-Theileria parva infection. It is concluded from structure-activity studies that a 2-hydroxyl moiety es essential for high activity. The most active compounds tested were 2-hydroxy-3-alkyl-1,4-naphthoquinones in which the alkyl moiety was cyclohexyl, cyclohexylcyclohexyl, tridecyl, or tetradecyl.
已经制备了多种萘醌，并在体外对牛病东海岸热的病原体——小泰累尔梨形虫感染进行了评估。结构活性研究得出结论，2-羟基部分对于高活性至关重要。测试的最具活性的化合物是2-羟基-3-烷基-1,4-萘醌，其中烷基部分为环己基、环己基环己基、十三烷基或十四烷基。
