Sudhakar Patil Vinit, Rupa Bavaskar Kedar, Omprakash Morani Dilip, Suresh Jain Ashish
Shri D.D. Vispute College of Pharmacy and Research Center, Devad-Vichumbe, New Panvel, India-410206.
Department of Pharmaceutics, Shri D.D. Vispute College of Pharmacy and Research Center, Devad-Vichumbe, New Panvel, India-410206.
Adv Pharm Bull. 2024 Jul;14(2):266-277. doi: 10.34172/apb.2024.043. Epub 2024 Mar 17.
Many people lose their lives to cancer each year. The prevalence of illnesses, metabolic disorders, high-risk infections, and other conditions has been greatly slowed down by expanding scientific research. Chemotherapy and radiation are still the initial lines of treatment for cancer patients, along with surgical removal of tumors. Modifications have been made in chemotherapy since medicines frequently have substantial systemic toxicity and poor pharmacokinetics and still do not reach the tumor site at effective concentrations. Chemotherapy may now be administered more safely and effectively thanks to nanotechnology. Nanotechnology-based graphene quantum dots (GQDs) are very applicable in breast cancer detection, as a drug delivery system, and in the treatment of breast cancer because of their physical and chemical properties, lower toxicity, small size, fluorescence, and effective drug delivery. This paper analyzes the GQDs as cutting-edge platforms for biotechnology and nanomedicine also its application in drug delivery in cancer. It shows that GQDs can be effectively conjugated with hyaluronic acid (HA) to achieve efficient and target-specific delivery.
每年都有许多人死于癌症。通过扩大科学研究,疾病、代谢紊乱、高风险感染和其他病症的流行率已大幅放缓。化疗和放疗仍然是癌症患者的初始治疗手段,同时还有肿瘤的手术切除。由于药物常常具有显著的全身毒性和不良的药代动力学,且仍无法以有效浓度到达肿瘤部位,因此化疗方法已经有所改进。借助纳米技术,现在可以更安全、有效地进行化疗。基于纳米技术的石墨烯量子点(GQDs)因其物理和化学性质、较低的毒性、小尺寸、荧光以及有效的药物递送,在乳腺癌检测、作为药物递送系统以及乳腺癌治疗中非常适用。本文分析了石墨烯量子点作为生物技术和纳米医学的前沿平台及其在癌症药物递送中的应用。研究表明,石墨烯量子点可以与透明质酸(HA)有效结合,以实现高效的靶向递送。