Omidian Hossein, Wilson Renae L, Cubeddu Luigi X
Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Materials (Basel). 2024 May 4;17(9):2152. doi: 10.3390/ma17092152.
The multifaceted role of quantum dots (QDs) in breast cancer research highlights significant advancements in diagnostics, targeted therapy, and drug delivery systems. This comprehensive review addresses the development of precise imaging techniques for early cancer detection and the use of QDs in enhancing the specificity of therapeutic delivery, particularly in challenging cases like triple-negative breast cancer (TNBC). The paper also discusses the critical understanding of QDs' interactions with cancer cells, offering insights into their potential for inducing cytotoxic effects and facilitating gene therapy. Limitations such as biocompatibility, toxicity concerns, and the transition from laboratory to clinical practice are critically analyzed. Future directions emphasize safer, non-toxic QD development, improved targeting mechanisms, and the integration of QDs into personalized medicine, aiming to overcome the current challenges and enhance breast cancer management.
量子点(QDs)在乳腺癌研究中的多方面作用凸显了诊断、靶向治疗和药物递送系统方面的重大进展。这篇全面综述探讨了用于早期癌症检测的精确成像技术的发展,以及量子点在提高治疗递送特异性方面的应用,特别是在三阴性乳腺癌(TNBC)等具有挑战性的病例中。本文还讨论了对量子点与癌细胞相互作用的关键理解,深入了解了它们诱导细胞毒性作用和促进基因治疗的潜力。对生物相容性、毒性问题以及从实验室到临床实践的转变等局限性进行了批判性分析。未来的方向强调开发更安全、无毒的量子点,改进靶向机制,并将量子点整合到个性化医疗中,旨在克服当前挑战并加强乳腺癌管理。