MEMS, Microfluidics and Nanoelectronics (MMNE) Lab, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, 500 078, Telangana, India.
Department of Electrical and Electronics Engineering, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, 500 078, Telangana, India.
Anal Methods. 2024 Sep 19;16(36):6098-6118. doi: 10.1039/d4ay01030b.
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancers. OSCC constitutes 90% of the head and neck malignancies. The delayed identification of oral cancer is the primary cause of ineffective medical treatment. To address this issue, low-cost, reliable point-of-care devices that can be utilized for large-scale screening, even in low-resource settings, including rural areas and primary healthcare centers, are of great interest. Herein, a comprehensive analysis of numerous salivary biomarkers that exhibit significant variations in concentration between individuals with oral cancer and those without is given. Furthermore, the article explores several point-of-care devices that exhibit potential in the realm of oral cancer detection. The biomarkers are discussed with a focus on their structural characteristics and role in oral cancer progression. The devices based on colorimetry and microfluidics are discussed in detail, considering their compliance with the 'REASSURED' criteria given by the World Health Organization (WHO) and suitability for mass screening in low-resource settings. Finally, the discourse revolves around the fundamental aspects pertaining to the advancement of multiplex, cost-effective point-of-care devices designed for widespread screening purposes.
口腔鳞状细胞癌（OSCC）是最常见的头颈部癌症。OSCC 占头颈部恶性肿瘤的 90%。口腔癌的诊断延迟是治疗效果不佳的主要原因。为了解决这个问题，人们对低成本、可靠的即时检测设备产生了浓厚的兴趣，这些设备可用于大规模筛查，甚至在资源有限的环境中，包括农村地区和初级保健中心。本文全面分析了许多唾液生物标志物，这些生物标志物在口腔癌患者和非口腔癌患者中的浓度存在显著差异。此外，本文还探讨了几种在口腔癌检测领域具有应用潜力的即时检测设备。本文重点讨论了这些生物标志物的结构特征及其在口腔癌进展中的作用。详细讨论了基于比色法和微流控技术的设备，考虑了它们与世界卫生组织（WHO）提出的“REASSURED”标准的符合性以及在资源有限环境中进行大规模筛查的适用性。最后，本文讨论了为广泛筛查目的而设计的、具有多重功能且经济实惠的即时检测设备的关键方面。
