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当在免疫球蛋白重链基因座（Igh）同基因宿主中发育时，抑制性T细胞因子呈现出Igh基因限制的改变模式。

Suppressor T-cell factor(s) display an altered pattern of Igh (immunoglobulin heavy chain locus) genetic restriction when developed in an Igh-congeneic host.

作者信息

HayGlass K T, Naides S J, Benacerraf B, Sy M S

出版信息

Proc Natl Acad Sci U S A. 1985 Apr;82(7):2133-7. doi: 10.1073/pnas.82.7.2133.

DOI:10.1073/pnas.82.7.2133
PMID:3920661
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC397507/
Abstract

Suppressor T-cell factor(s) (TsF1) inhibit the in vivo priming of azobenzenearsonate-specific cytotoxic T-cell responses. The activity of TsF1 is restricted by genes linked to Igh-1 allotypic markers. TsF1 obtained from B6.Igh-1n mice was unable to suppress the immune response in B6.Igh-1b mice and vice versa. However, TsF1 prepared from B6.Igh-1n T cells "parked" in an Igh-congeneic B6.Igh-1b environment displays an additional restriction specificity of the host. Thus, TsF1 prepared from these Igh-chimeric mice suppressed immune responses in both B6.Igh-1n (donor) and B6.Igh-1b (recipient) mice but not in mice of the unrelated strain BALB/c.Igh-1a. The results indicate that the establishment of the suppressor T-cell repertoire is dependent not only upon the genetic background of the individual T cell but also upon the influence of Igh-linked determinants present when T-cell clones are selected during the response.

摘要

抑制性T细胞因子（TsF1）可抑制体内偶氮苯砷酸盐特异性细胞毒性T细胞反应的启动。TsF1的活性受与Igh-1同种异型标记相关基因的限制。从B6.Igh-1n小鼠获得的TsF1无法抑制B6.Igh-1b小鼠的免疫反应，反之亦然。然而，从“驻留”于Igh同基因B6.Igh-1b环境中的B6.Igh-1n T细胞制备的TsF1表现出宿主的另一种限制特异性。因此，从这些Igh嵌合小鼠制备的TsF1可抑制B6.Igh-1n（供体）和B6.Igh-1b（受体）小鼠的免疫反应，但不能抑制无关品系BALB/c.Igh-1a小鼠的免疫反应。结果表明，抑制性T细胞库的建立不仅取决于单个T细胞的遗传背景，还取决于在反应过程中选择T细胞克隆时存在的Igh连锁决定簇的影响。

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Suppressor T-cell factor(s) display an altered pattern of Igh (immunoglobulin heavy chain locus) genetic restriction when developed in an Igh-congeneic host.当在免疫球蛋白重链基因座（Igh）同基因宿主中发育时，抑制性T细胞因子呈现出Igh基因限制的改变模式。
Proc Natl Acad Sci U S A. 1985 Apr;82(7):2133-7. doi: 10.1073/pnas.82.7.2133.
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Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus.抗原特异性抑制性和增强性T细胞因子上的两种不同的同种异型决定簇，它们由与免疫球蛋白重链基因座连锁的基因编码。
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Igh variable region-restricted T cell interactions. Genetic restriction of an antigen-specific suppressor inducer factor is imparted by an I-J+ antigen-nonspecific molecule.免疫球蛋白重链可变区限制的T细胞相互作用。抗原特异性抑制诱导因子的遗传限制由一种I-J +抗原非特异性分子赋予。
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引用本文的文献

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Turning (Ir gene) low responders into high responders by antibody manipulation of the developing immune system.通过对发育中的免疫系统进行抗体调控，将（Ir基因）低反应者转变为高反应者。
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3812-6. doi: 10.1073/pnas.84.11.3812.
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T cell development in B cell-deficient mice. V. Stopping anti-mu treatment results in Igh-restricted expansion of the T suppressor cell repertoire concomitant with the development of normal immunoglobulin levels.B细胞缺陷小鼠中的T细胞发育。V. 停止抗μ治疗会导致T抑制细胞库的Igh限制性扩增，并伴随着正常免疫球蛋白水平的发展。
J Exp Med. 1986 Jul 1;164(1):36-49. doi: 10.1084/jem.164.1.36.

本文引用的文献

1
A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment.一株T15独特型阳性的抑制性T杂交瘤不使用T15重链可变区基因片段。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6984-8. doi: 10.1073/pnas.79.22.6984.
2
Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs.T淋巴细胞的群体动力学。外周淋巴器官中的更新率和扩增
J Immunol. 1983 Nov;131(5):2158-64.
3
Biologic activity of an idiotype-bearing suppressor T cell factor produced by a long-term T cell hybridoma.长期T细胞杂交瘤产生的携带独特型的抑制性T细胞因子的生物学活性。
J Immunol. 1982 Jan;128(1):49-53.
4
The expression of idiotypic determinants on suppressor T cells is independent of T cell Igh genotype.抑制性T细胞上独特型决定簇的表达与T细胞免疫球蛋白重链基因型无关。
J Mol Cell Immunol. 1984;1(5):293-304.
5
Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of murine suppressor T-cell factors.用兔抗小鼠μ链抗体进行长期治疗会改变小鼠抑制性T细胞因子特征性的免疫球蛋白重链限制。
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3846-50. doi: 10.1073/pnas.81.12.3846.
6
Suppressor T cell circuits.
Ann N Y Acad Sci. 1982;392:300-8. doi: 10.1111/j.1749-6632.1982.tb36115.x.
7
Regulation of immunity to the azobenzenearsonate hapten.对偶氮苯胂酸盐半抗原免疫的调节
Adv Immunol. 1982;32:253-300. doi: 10.1016/s0065-2776(08)60723-3.
8
T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segments.识别相同抗原的T细胞和B细胞不会转录相似的重链可变区基因片段。
J Exp Med. 1983 Jul 1;158(1):192-209. doi: 10.1084/jem.158.1.192.
9
Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes.细胞溶解性T淋巴细胞库与免疫球蛋白重链基因的遗传连锁
J Exp Med. 1982 Jul 1;156(1):294-9. doi: 10.1084/jem.156.1.294.
10
Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells.抗原和受体驱动的调节机制。VII. 来自传出抑制性T细胞的H-2限制性抗独特型抑制因子。
J Exp Med. 1981 Feb 1;153(2):450-63. doi: 10.1084/jem.153.2.450.

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