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1
Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells.抗原和受体驱动的调节机制。VII. 来自传出抑制性T细胞的H-2限制性抗独特型抑制因子。
J Exp Med. 1981 Feb 1;153(2):450-63. doi: 10.1084/jem.153.2.450.
2
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.抗原和受体驱动的调节机制。IV. 携带独特型的I-J+抑制性T细胞因子诱导表达抗独特型受体的二级抑制性T细胞。
J Exp Med. 1980 May 1;151(5):1183-95. doi: 10.1084/jem.151.5.1183.
3
Hapten-specific responses to the phenyltrimethylamino hapten. IV. Occurrence of mechanistically distinct idiotypic suppressor T cells before the appearance of anti-idiotypic suppressor T cells induced by the monovalent antigen L-tyrosine-p-azophenyltrimethylammonium.对半抗原苯三甲基氨基的半抗原特异性反应。IV. 在由单价抗原L-酪氨酸对偶氮苯三甲基铵诱导的抗独特型抑制性T细胞出现之前，机制不同的独特型抑制性T细胞的出现。
J Immunol. 1983 Jun;130(6):2519-24.
4
Antigen and receptor-driven regulatory mechanisms. VI. Demonstration of cross-reactive idiotypic determinants on azobenzenearsonate-specific antigen-binding suppressor T cells producing soluble suppressor factor(s).抗原和受体驱动的调节机制。VI. 对偶氮苯胂酸盐特异性抗原结合抑制性T细胞上产生可溶性抑制因子的交叉反应性独特型决定簇的证明。
J Immunol. 1980 Dec;125(6):2374-9.
5
Hapten-specific responses to the phenyltrimethylamino hapten. V. A single chain antigen-binding I-J+ first-order T suppressor factor requires antigen to induce anti-idiotypic second-order suppressor T cells.对半抗原苯三甲基氨基的半抗原特异性反应。V. 单链抗原结合性I-J⁺一级T抑制因子需要抗原诱导抗独特型二级抑制性T细胞。
J Immunol. 1985 Feb;134(2):1010-8.
6
T cell development in B cell-deficient mice. II. Serological characterization of suppressor T cell factors (TsF1) produced in normal mice and in mice treated chronically with rabbit anti-mouse IgM antibodies.B细胞缺陷小鼠中的T细胞发育。II. 正常小鼠及长期用兔抗小鼠IgM抗体处理的小鼠中产生的抑制性T细胞因子（TsF1）的血清学特征
J Exp Med. 1985 Jun 1;161(6):1402-13. doi: 10.1084/jem.161.6.1402.
7
Antigen- and receptor-driven regulatory mechanisms. III. Induction of delayed type hypersensitivity to azobenzenearsonate with anti-cross-reactive idiotypic antibodies.抗原和受体驱动的调节机制。III. 用抗交叉反应性独特型抗体诱导对偶氮苯砷酸盐的迟发型超敏反应。
J Exp Med. 1980 Apr 1;151(4):896-909. doi: 10.1084/jem.151.4.896.
8
Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate-primed T cell target.抗原和受体驱动的调节机制。VIII. 抗独特型二级T抑制细胞与交叉反应性独特型阳性、对氨基苯砷酸致敏的T细胞靶标的相互作用导致对独特型阴性、对氨基苯砷酸特异性T细胞的抑制。
J Exp Med. 1981 Jun 1;153(6):1415-25. doi: 10.1084/jem.153.6.1415.
9
Antigen-specific suppressor T cell interactions. I. Induction of an MHC-restricted suppressor factor specific for L-glutamic acid50-L-tyrosine50.抗原特异性抑制性T细胞相互作用。I. 对L-谷氨酸50-L-酪氨酸50特异的MHC限制性抑制因子的诱导。
J Immunol. 1982 Jun;128(6):2447-52.
10
Antigen- and receptor-driven regulatory mechanisms. V. The failure of idiotype-coupled spleen cells to induce unresponsiveness in animals lacking the appropriate VH genes is caused by the lack of idiotype-matched targets.抗原和受体驱动的调节机制。五、在缺乏适当VH基因的动物中，独特型偶联的脾细胞未能诱导无反应性是由于缺乏独特型匹配的靶细胞。
J Exp Med. 1980 Nov 1;152(5):1226-35. doi: 10.1084/jem.152.5.1226.

引用本文的文献

1
Tolerance, suppression and the fetal allograft.耐受性、抑制作用与胎儿同种异体移植物
J Mol Med (Berl). 2005 Feb;83(2):88-96. doi: 10.1007/s00109-004-0608-2. Epub 2004 Dec 17.
2
Antigen-specific suppressor T cell interactions. II. Characterization of two different types of suppressor T cell factors specific for L-glutamic acid50-L-tyrosine50 (GT) and L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).抗原特异性抑制性T细胞相互作用。II. 对两种不同类型的、分别针对L-谷氨酸50-L-酪氨酸50（GT）和L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的抑制性T细胞因子的特性分析。
J Exp Med. 1983 Dec 1;158(6):1962-78. doi: 10.1084/jem.158.6.1962.
3
Suppressor factor from a T cell hybrid inhibits delayed-type hypersensitivity responses to azobenzenearsonate.来自T细胞杂交体的抑制因子可抑制对偶氮苯砷酸盐的迟发型超敏反应。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6441-5. doi: 10.1073/pnas.78.10.6441.
4
Antigen- and receptor-driven regulatory mechanisms. VIII. Suppression of idiotype-negative, p-azobenzenearsonate-specific T cells results from the interaction of an anti-idiotypic second-order T suppressor cell with a cross-reactive-idiotype-positive, p-azobenzenearsonate-primed T cell target.抗原和受体驱动的调节机制。VIII. 抗独特型二级T抑制细胞与交叉反应性独特型阳性、对氨基苯砷酸致敏的T细胞靶标的相互作用导致对独特型阴性、对氨基苯砷酸特异性T细胞的抑制。
J Exp Med. 1981 Jun 1;153(6):1415-25. doi: 10.1084/jem.153.6.1415.
5
I-J-restricted interactions in the generation of azobenzenearsonate-specific suppressor T cells.偶氮苯胂酸盐特异性抑制性T细胞产生过程中的I-J限制相互作用。
J Exp Med. 1982 Nov 1;156(5):1325-34. doi: 10.1084/jem.156.5.1325.
6
Abnormalities of third-order suppressor T cells in old (New Zealand black x New Zealand white) F1 mice.老年（新西兰黑鼠×新西兰白鼠）F1代小鼠中三阶抑制性T细胞的异常情况。
Immunology. 1984 Nov;53(3):553-61.
7
Suppressor T cell growth and differentiation. Identification of a cofactor required for suppressor T cell function and distinct from interleukin 2.抑制性T细胞的生长与分化。鉴定一种抑制性T细胞功能所需且不同于白细胞介素2的辅助因子。
J Exp Med. 1984 May 1;159(5):1473-90. doi: 10.1084/jem.159.5.1473.
8
Igh variable region-restricted T cell interactions. Genetic restriction of an antigen-specific suppressor inducer factor is imparted by an I-J+ antigen-nonspecific molecule.免疫球蛋白重链可变区限制的T细胞相互作用。抗原特异性抑制诱导因子的遗传限制由一种I-J +抗原非特异性分子赋予。
J Exp Med. 1983 Dec 1;158(6):1938-47. doi: 10.1084/jem.158.6.1938.
9
Structure of antigen-specific suppressor factors: current views.抗原特异性抑制因子的结构：当前观点
Surv Immunol Res. 1982;1(1):17-23. doi: 10.1007/BF02918237.
10
An antigen-specific signal is required for the activation of second-order suppressor T cells in the regulation of delayed-type hypersensitivity to 2,4,6-trinitrobenzene sulfonic acid.在对2,4,6-三硝基苯磺酸迟发型超敏反应的调节中，二阶抑制性T细胞的激活需要抗原特异性信号。
J Exp Med. 1983 Sep 1;158(3):932-45. doi: 10.1084/jem.158.3.932.

本文引用的文献

1
Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.利用具有独特型或抗独特型受体的可溶性T细胞衍生因子选择性抑制抗半抗原反应的主要独特型成分。
J Exp Med. 1980 May 1;151(5):1213-31. doi: 10.1084/jem.151.5.1213.
2
Helper and suppressor T cell factors.辅助性和抑制性T细胞因子。
Springer Semin Immunopathol. 1980 May;3(1):93-127. doi: 10.1007/BF00199927.
3
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. III. Interaction of effector suppressor T cells is restricted by H-2 and Igh-V genes.对半抗原4-羟基-3-硝基苯乙酰的半抗原特异性T细胞应答。III. 效应性抑制性T细胞的相互作用受H-2和免疫球蛋白重链可变区（Igh-V）基因的限制。
J Exp Med. 1980 Jun 1;151(6):1413-23. doi: 10.1084/jem.151.6.1413.
4
Suppressive mechanisms involving sensitization and tolerance in contact allergy.接触性过敏中涉及致敏和耐受的抑制机制。
Immunol Rev. 1980;50:105-32. doi: 10.1111/j.1600-065x.1980.tb00309.x.
5
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.抗原和受体驱动的调节机制。IV. 携带独特型的I-J+抑制性T细胞因子诱导表达抗独特型受体的二级抑制性T细胞。
J Exp Med. 1980 May 1;151(5):1183-95. doi: 10.1084/jem.151.5.1183.
6
Role of self carriers in the immune response and tolerance. V. Reversal of trinitrophenyl-modified self suppression of the B-cell response by blocking of H-2 antigens.自身载体在免疫应答和耐受性中的作用。V. 通过阻断H-2抗原逆转三硝基苯基修饰的自身对B细胞应答的抑制作用。
J Exp Med. 1980 Jan 1;151(1):133-43. doi: 10.1084/jem.151.1.133.
7
Antigen- and receptor-driven regulatory mechanisms. V. The failure of idiotype-coupled spleen cells to induce unresponsiveness in animals lacking the appropriate VH genes is caused by the lack of idiotype-matched targets.抗原和受体驱动的调节机制。五、在缺乏适当VH基因的动物中，独特型偶联的脾细胞未能诱导无反应性是由于缺乏独特型匹配的靶细胞。
J Exp Med. 1980 Nov 1;152(5):1226-35. doi: 10.1084/jem.152.5.1226.
8
Antigen and receptor-driven regulatory mechanisms. VI. Demonstration of cross-reactive idiotypic determinants on azobenzenearsonate-specific antigen-binding suppressor T cells producing soluble suppressor factor(s).抗原和受体驱动的调节机制。VI. 对偶氮苯胂酸盐特异性抗原结合抑制性T细胞上产生可溶性抑制因子的交叉反应性独特型决定簇的证明。
J Immunol. 1980 Dec;125(6):2374-9.
9
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞反应。V. 独特型在抑制途径中的作用。
J Exp Med. 1980 Jul 1;152(1):161-9. doi: 10.1084/jem.152.1.161.
10
Depression of the T cell phenomenon of contact sensitivity by T cells from unresponsive mice.无反应小鼠的T细胞对接触敏感性T细胞现象的抑制作用。
Nature. 1973 Jul 27;244(5413):227-8. doi: 10.1038/244227a0.

抗原和受体驱动的调节机制。VII. 来自传出抑制性T细胞的H-2限制性抗独特型抑制因子。

Antigen- and receptor-driven regulatory mechanisms. VII. H-2-restricted anti-idiotypic suppressor factor from efferent suppressor T cells.

作者信息

Dietz M H, Sy M S, Benacerraf B, Nisonoff A, Greene M I, Germain R N

出版信息

J Exp Med. 1981 Feb 1;153(2):450-63. doi: 10.1084/jem.153.2.450.

DOI:10.1084/jem.153.2.450
PMID:6165799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186080/
Abstract

Azobenzenearsonate (ABA)-specific T cell-derived suppressor factor (TsF1) from A/J mice was used to induced second-order suppressor T cells (Ts2). Comparison of suppressor T cells induced by antigen (Ts1) with Ts2 induced by TsF1 revealed that Ts1 were afferent suppressors active only when given at the time of antigen priming, and not thereafter, whereas Ts2 could act when transferred at any time up to 1 d before antigen challenge for a delayed-type hypersensitivity response. This was true even when the recipient could be shown to be fully immune before transfer of Ts2, thus defining these cells as efferent suppressors. The anti-idiotypic specificity of the Ts2 was demonstrated by the ability of Ts to bind to idiotype (cross-reactive idiotype [CRI])-coated Petri dishes. A soluble extract from Ts2 (TsF2) was also capable of mediating efferent suppression that was functionally antigen- (ABA) specific. Comparison of TsF1 with this new factor, TsF2, revealed that both lack Ig-constant-region determinants, possess H-2-coded determinants, and show specific binding (to ABA and to CRI+-Ig, respectively). TsF1 acts in strains that differ with respect to H-2 and background genes, whereas TsF2 shows H-2- and non-H-2-linked genetic restrictions. This existence of H-2 restriction of TsF2 activity suggests that the apparent discrepancies in studies of H-2 restriction of TsF may be a result of the analysis of two separate classes of TsF, only one of which shows genetically restricted activity, thus unifying several models of suppressor cell activity.

摘要

来自A/J小鼠的偶氮苯砷酸盐（ABA）特异性T细胞衍生抑制因子（TsF1）被用于诱导二级抑制性T细胞（Ts2）。将抗原诱导的抑制性T细胞（Ts1）与TsF1诱导的Ts2进行比较，结果显示Ts1是传入性抑制因子，仅在抗原初次免疫时给予才具有活性，之后则无活性，而Ts2在抗原激发迟发型超敏反应前1天内的任何时间转移时都能发挥作用。即使在转移Ts2之前受体已被证明具有完全免疫性，情况依然如此，因此将这些细胞定义为传出性抑制因子。Ts2的抗独特型特异性通过Ts与独特型（交叉反应独特型[CRI]）包被的培养皿结合的能力得以证明。Ts2的可溶性提取物（TsF2）也能够介导具有功能抗原（ABA）特异性的传出性抑制。将TsF1与这个新因子TsF2进行比较，结果显示二者均缺乏Ig恒定区决定簇，但具有H-2编码的决定簇，并且分别显示出特异性结合（分别针对ABA和CRI+-Ig）。TsF1在H-2和背景基因不同的品系中发挥作用，而TsF2表现出H-2和非H-2连锁的遗传限制。TsF2活性存在H-2限制这一现象表明，TsF的H-2限制研究中明显的差异可能是由于对两类不同的TsF进行分析的结果，其中只有一类显示出遗传限制活性，从而统一了几种抑制性细胞活性模型。