尼泊尔版男性雄激素缺乏在老龄化男性中定量评估（qADAM）问卷在糖尿病患者中的敏感性和特异性。

Sensitivity and Specificity of Nepali Version of Quantitative Androgen Deficiency in Aging Males (qADAM) Questionnaire in Diabetic Patients.

机构信息

Department of Clinical Biochemistry, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Science, Dhulikhel, Kavre, Nepal. Wuhan University, Faculty of Medical Sciences, School of Public Health, China.

Department of Clinical Biochemistry, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Science, Dhulikhel, Kavre, Nepal.

出版信息

Kathmandu Univ Med J (KUMJ). 2023 Jul-Sep;21(83):275-280.

PMID:39206646

Abstract

Background Diabetes mellitus (DM) is a chronic disorder with hyperglycemia that affects multiple systems with hypogonadism and erectile dysfunction some common issues affecting their quality sexual life. Quantitative androgen deficiency in aging males (qADAM) questionnaire is a trusted tool to assess hypogonadism and erectile dysfunction among diabetic patients and has been commonly used in Nepal too. However, the accuracy, sensitivity, and specificity of its Nepali version are yet to be tested. Objective To assess the accuracy, sensitivity, and specificity of the Nepali version of the quantitative androgen deficiency in aging males questionnaire among diabetic patients. Method A cross-sectional study was conducted among diabetic patients attending Dhulikhel Hospital, Kathmandu University Hospital. The Patients were asked to complete the valid Nepali translated version of quantitative Androgen Deficiency in Aging Males questionnaire. Participants' serum total and free testosterone, lipid profile, fasting blood glucose, HbA1c and Sex Hormone Binding Globulin (SHBG) were measured in clinical biochemistry laboratory and the accuracy, sensitivity and specificity of Nepali version of quantitative androgen deficiency in aging males were analyzed. Result The translated Nepali version of quantitative androgen deficiency in aging males questionnaire showed 61.9% sensitivity, 45.5% specificity, and 56.7% accuracy in diagnosing hypogonadism in reference to serum testosterone level. Conclusion This Nepali translated version of quantitative androgen deficiency in aging males questionnaire can be a noninvasive tool to assess hypogonadism and erectile dysfunction.

摘要

背景糖尿病（DM）是一种慢性高血糖疾病，会影响多个系统，导致性腺功能减退和勃起功能障碍等常见问题，影响其性生活质量。定量雄激素缺乏在老年男性（qADAM）问卷是一种评估糖尿病患者性腺功能减退和勃起功能障碍的可靠工具，在尼泊尔也得到了广泛应用。然而，其尼泊尔语版本的准确性、敏感性和特异性尚未得到验证。目的评估糖尿病患者使用尼泊尔语版定量雄激素缺乏在老年男性问卷的准确性、敏感性和特异性。方法这是一项在加德满都大学医院和Dhulikhel 医院就诊的糖尿病患者中进行的横断面研究。要求患者完成有效的尼泊尔语翻译版定量雄激素缺乏在老年男性问卷。在临床生化实验室测量参与者的血清总睾酮和游离睾酮、血脂谱、空腹血糖、HbA1c 和性激素结合球蛋白（SHBG），并分析尼泊尔语版定量雄激素缺乏在老年男性问卷的准确性、敏感性和特异性。结果与血清睾酮水平相比，尼泊尔语翻译版定量雄激素缺乏在老年男性问卷的诊断性腺功能减退的敏感性为 61.9%，特异性为 45.5%，准确性为 56.7%。结论尼泊尔语翻译版定量雄激素缺乏在老年男性问卷可作为一种非侵入性工具，用于评估性腺功能减退和勃起功能障碍。