Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.
Department of Internal Medicine, Cardiology Unit, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.
Kathmandu Univ Med J (KUMJ). 2023 Jul-Sep;21(83):309-314.
Background Thyroid dysfunction and associated factors like age, sex, diabetes mellitus, hypertension, smoking, family history of coronary artery disease and dyslipidemia contributes the risk for acute coronary syndrome. Objective To find out the prevalence of thyroid dysfunction and associated risk factors among acute coronary syndrome patients at this tertiary care hospital in eastern Nepal. Method A descriptive cross-sectional study was carried out prospectively among acute coronary syndrome patients at a tertiary care Hospital. Diagnosis of acute coronary syndrome was made based on the medical history, Electrocardiogram abnormalities, and cardiac markers. Thyroid function test and estimation of other blood parameters were done in the blood of the patients. Other relevant information and medical history of the patients were collected by using proforma. Result Out of 186 total acute coronary syndrome patients, 127 (68.28%) were male and mean age of all patients was 60.0 ± 13.7 years. Thyroid dysfunction was observed in 52 (27.95%) patients, out of that subclinical hypothyroidism was mostly seen in 30 (16.12%) patients followed by hypothyroidism in 13 (6.98%). The number of patients with hyperthyroidism and subclinical hyperthyroidism was 6 (3.23%) and 3 (1.62%) respectively. Associated factors like hypertension, diabetes mellitus, smoking, family history of coronary artery disease and dyslipidemia was observed in 80 (43.01%), 42 (22.58%), 83 (44.62%), 11 (5.91%) and 79 (42.47%) patients. Conclusion Acute coronary syndrome was predominantly seen in male and subclinical hypothyroidism was a major thyroid dysfunction observed among the patients. Hypertension, dyslipidemia, diabetes mellitus and smoking was found to be associated in a proportion of patients with acute coronary syndrome.
甲状腺功能障碍以及相关因素，如年龄、性别、糖尿病、高血压、吸烟、冠心病家族史和血脂异常，都会增加急性冠状动脉综合征的风险。目的：在尼泊尔东部的一家三级保健医院，发现甲状腺功能障碍及相关危险因素在急性冠状动脉综合征患者中的流行情况。方法：前瞻性地对一家三级保健医院的急性冠状动脉综合征患者进行描述性横断面研究。急性冠状动脉综合征的诊断基于病史、心电图异常和心脏标志物。对患者的血液进行甲状腺功能检查和其他血液参数的评估。通过使用表格收集患者的其他相关信息和病史。结果：在 186 例急性冠状动脉综合征患者中，127 例（68.28%）为男性，所有患者的平均年龄为 60.0 ± 13.7 岁。52 例（27.95%）患者存在甲状腺功能障碍，其中亚临床甲状腺功能减退症最为常见，有 30 例（16.12%），其次是甲状腺功能减退症 13 例（6.98%）。甲状腺功能亢进症和亚临床甲状腺功能亢进症患者分别为 6 例（3.23%）和 3 例（1.62%）。高血压、糖尿病、吸烟、冠心病家族史和血脂异常等相关因素在 80 例（43.01%）、42 例（22.58%）、83 例（44.62%）、11 例（5.91%）和 79 例（42.47%）患者中存在。结论：急性冠状动脉综合征主要发生在男性中，亚临床甲状腺功能减退症是患者中主要的甲状腺功能障碍。高血压、血脂异常、糖尿病和吸烟与急性冠状动脉综合征患者的一部分相关。
