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青春期生育对一生中残疾的贡献:假设的因果途径、研究空白和未来方向。

The contributions of fertility during adolescence to disability across the life-course: hypothesized causal pathways, research gaps, and future directions.

机构信息

Office of Public Health Studies, University of Hawai'i at Mānoa, Honolulu, HI, USA.

Departments of Obstetrics and Gynaecology & Public Health Sciences, Queen's University, Kingston, Canada.

出版信息

Ann Hum Biol. 2024 Feb;51(1):2390829. doi: 10.1080/03014460.2024.2390829. Epub 2024 Aug 29.

Abstract

CONTEXT

Robust associations have been identified between fertility during adolescence and the disablement process, including pathologies, impairments, functional limitations and disability. Limited theoretical or empirical research considers how and why such relationships exist generally or with the individual associated components of disablement.

OBJECTIVE

To consolidate and critically evaluate literature to describe testable, theory-based hypotheses to guide future research on the mechanisms by which fertility during adolescence contributes to disablement.

METHODS

Targeted literature review of research from diverse global settings contextualised in two well-accepted theoretical frameworks in life-course epidemiology: the cumulative risk model and the critical period approach.

RESULTS

Five hypothesised causal pathways linking adolescent fertility to disablement in later life are described: 1) initiated by fertility during adolescence; 2) , such as adverse childhood experiences; 3) to adolescent fertility; 4) between adolescent fertility and other risk factors; and 5) unique to adolescence. Most research on the topic is on pathologies versus functional limitations and disability.

CONCLUSION

We highlight promising research avenues to inform future research and interventions on adolescent fertility and the disablement process. This work provides theoretical clarity, identifies research gaps, and offers hypotheses-testing opportunities for future research.

摘要

背景

青春期生育与失能过程之间存在着强有力的关联,包括各种病理、损伤、功能限制和残疾。有限的理论或实证研究考虑了一般情况下或与失能的各个相关组成部分相关的这种关系是如何以及为什么存在的。

目的

综合和批判性地评估文献,以描述可检验的、基于理论的假设,指导青春期生育对失能影响机制的未来研究。

方法

在生命历程流行病学中两个公认的理论框架(累积风险模型和关键期方法)的背景下,对来自不同全球背景的研究进行有针对性的文献回顾。

结果

描述了五个假设的因果途径,将青春期生育与晚年失能联系起来:1)由青春期生育引发;2)通过中介因素,如不良的童年经历;3)通过其他风险因素影响青春期生育;4)在青春期生育和其他风险因素之间;5)青春期特有的。该主题的大多数研究都是针对病理与功能限制和残疾的关系。

结论

我们强调了有前途的研究途径,以为青春期生育和失能过程的未来研究和干预提供信息。这项工作提供了理论上的清晰性,确定了研究空白,并为未来的研究提供了假设检验的机会。

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