Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan, China.
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, China.
J Cancer Res Ther. 2024 Aug 1;20(4):1130-1140. doi: 10.4103/jcrt.jcrt_32_24. Epub 2024 Aug 29.
Intestinal microecology (IM) is the largest and most important microecological system of the human body. Furthermore, it is the key factor for activating and maintaining the physiological functions of the intestine. Numerous studies have investigated the effects of the gut microbiota on the different tissues and organs of the human body as well as their association with various diseases, and the findings are gradually being translated into clinical practice. The gut microbiota affects the occurrence, progression, treatment response, and toxic side effects of tumors. The deepening of research related to IM and tumors has opened a new chapter in IM research driven by methods and technologies such as second-generation sequencing and bioinformatics. The IM maintains the function of the host immune system and plays a pivotal role in tumor-control drug therapy. Increasing evidence has proven that the efficacy of tumor-control drugs largely depends on the IM balance, and strategies based on the IM technology show promising application prospects in the diagnosis and treatment of tumor. The Tumor and Microecology Professional Committee of the Chinese Anti-cancer Association gathered relevant experts to discuss and propose the "Chinese guidelines for integrated diagnosis and treatment of IM technologies in tumor application (2024 Edition)," which was established based on the research progress of the application of the IM technology in tumor to provide a basis for the standardization of the diagnosis and treatment of the IM technology in the tumor.
肠道微生态（IM）是人体最大、最重要的微生态系统，是激活和维持肠道生理功能的关键因素。大量研究已经探讨了肠道微生物群对人体不同组织和器官的影响及其与各种疾病的关联，研究结果逐渐转化为临床实践。肠道微生物群影响肿瘤的发生、发展、治疗反应和毒性副作用。对 IM 和肿瘤的深入研究，为基于二代测序和生物信息学等方法和技术的 IM 研究开辟了新篇章。IM 维持宿主免疫系统的功能，在肿瘤控制药物治疗中发挥关键作用。越来越多的证据证明，肿瘤控制药物的疗效在很大程度上取决于 IM 的平衡，基于 IM 技术的策略在肿瘤的诊断和治疗中显示出有前景的应用前景。中国抗癌协会肿瘤与微生态专业委员会召集相关专家进行讨论并提出“中国肿瘤应用肠道微生态技术整合诊断与治疗指南（2024 版）”，该指南基于 IM 技术在肿瘤应用中的研究进展，为肿瘤 IM 技术的诊断和治疗规范化提供依据。
