Guo Zhi, Lei Yumeng, Wang Qiang
Department of Hematology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong 518052, P.R. China.
Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei 430065, P.R. China.
Exp Ther Med. 2024 Aug 20;28(4):403. doi: 10.3892/etm.2024.12692. eCollection 2024 Oct.
The intestinal microbiota is a complex ecosystem that not only affects various physiological functions, such as metabolism, inflammation and the immune response, but also has an important effect on the development of tumors and response to treatment. The detection of intestinal flora enables the timely identification of disease-related flora abnormalities, which has significant implications for both disease prevention and treatment. In the field of basic and clinical research targeting gut microbiome, there is a need to recognize and understand the laboratory assays for gut microbiomics. Currently, there is no unified standard for the experimental procedure, quality management and report interpretation of intestinal microbiome assay technology. In order to clarify the process, the Tumor and Microecology Committee of China Anti-Cancer Association and the Tumor and Microecology Committee of Hubei Provincial Immunology Society organized relevant experts to discuss and put forward the standard technical specifications for gut microecomics laboratories, which provides a basis for further in-depth research in the field of intestinal microecomics.
肠道微生物群是一个复杂的生态系统，不仅影响各种生理功能，如新陈代谢、炎症和免疫反应，而且对肿瘤的发生发展及治疗反应也有重要影响。肠道菌群检测能够及时识别与疾病相关的菌群异常，这对疾病的预防和治疗都具有重要意义。在针对肠道微生物组的基础和临床研究领域，有必要认识和了解肠道微生物组学的实验室检测方法。目前，肠道微生物组检测技术的实验流程、质量管理及报告解读尚无统一标准。为明确相关流程，中国抗癌协会肿瘤与微生态专业委员会和湖北省免疫学会肿瘤与微生态专业委员会组织相关专家进行讨论，提出了肠道微生物组学实验室标准技术规范，为肠道微生物组学领域的进一步深入研究提供了依据。
