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老年综合评估:临床医生的为何、何为及如何做。

Geriatric assessment for the practicing clinician: The why, what, and how.

机构信息

Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA.

Department of Supportive Care, City of Hope, Antelope Valley, Duarte, California, USA.

出版信息

CA Cancer J Clin. 2024 Nov-Dec;74(6):496-518. doi: 10.3322/caac.21864. Epub 2024 Aug 29.

DOI:10.3322/caac.21864
PMID:39207229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11848937/
Abstract

Older adults with cancer heterogeneously experience health care, treatment, and symptoms. Geriatric assessment (GA) offers a comprehensive evaluation of an older individual's health status and can predict cancer-related outcomes in individuals with solid tumors and those with hematologic malignancies. In the last decade, randomized controlled trials have demonstrated the benefits of GA and GA management (GAM), which uses GA information to provide tailored intervention strategies to address GA impairments (e.g., implementing physical therapy for impaired physical function). Multiple phase 3 clinical trials in older adults with solid tumors and hematologic malignancies have demonstrated that GAM improves treatment completion, quality of life, communication, and advance care planning while reducing treatment-related toxicity, falls, and polypharmacy. Nonetheless, implementation and uptake of GAM remain challenging. Various strategies have been proposed, including the use of GA screening tools, to identify patients most likely to benefit from GAM, the systematic engagement of the oncology workforce in the delivery of GAM, and the integration of technologies like telemedicine and mobile health to enhance the availability of GA and GAM interventions. Health inequities in minoritized groups persist, and systematic GA implementation has the potential to capture social determinants of health that are relevant to equitable care. Caregivers play an important role in cancer care and experience burden themselves. GA can guide dyadic supportive care interventions, ultimately helping both patients and caregivers achieve optimal health.

摘要

老年癌症患者在医疗保健、治疗和症状方面存在差异。老年评估(GA)提供了对老年个体健康状况的全面评估,并可预测实体瘤和血液恶性肿瘤患者的癌症相关结局。在过去十年中,随机对照试验已经证明了 GA 和 GA 管理(GAM)的益处,GAM 利用 GA 信息提供定制的干预策略,以解决 GA 损害(例如,为身体功能受损的患者实施物理治疗)。多项针对老年实体瘤和血液恶性肿瘤患者的 3 期临床试验表明,GAM 可提高治疗完成率、生活质量、沟通能力和预先护理计划,同时降低治疗相关毒性、跌倒和多重用药。尽管如此,GAM 的实施和采用仍然具有挑战性。已经提出了各种策略,包括使用 GA 筛查工具来识别最有可能从 GAM 中受益的患者,系统地让肿瘤学工作者参与 GAM 的提供,以及整合远程医疗和移动健康等技术,以提高 GA 和 GAM 干预措施的可及性。少数族裔群体中仍然存在健康不平等,系统的 GA 实施有可能捕捉到与公平护理相关的健康决定因素。照顾者在癌症护理中扮演着重要的角色,他们自己也承受着负担。GA 可以指导双重视角的支持性护理干预,最终帮助患者和照顾者实现最佳健康。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4084/11848937/980a64f85659/nihms-2048163-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4084/11848937/5028b61a4402/nihms-2048163-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4084/11848937/980a64f85659/nihms-2048163-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4084/11848937/5028b61a4402/nihms-2048163-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4084/11848937/980a64f85659/nihms-2048163-f0002.jpg

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