Bird Brian M, Belisario Kyla, Murphy James G, Stewart Sherry H, MacKillop James
Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton, McMaster University.
Department of Psychology, University of Memphis.
Exp Clin Psychopharmacol. 2024 Dec;32(6):639-651. doi: 10.1037/pha0000735. Epub 2024 Aug 29.
A behavioral economic reinforcer pathology model theorizes that alcohol problems are influenced by steep delay discounting, overvaluation of alcohol reinforcement, and low reinforcement from alcohol-free activities. Extending this account to the comorbidity of alcohol problems and posttraumatic stress disorder (PTSD), the present study tested the hypothesis that alcohol problems and PTSD symptom severity would interact and be positively associated with indicators from these three domains. High-risk emerging adults from North America (Study 1, = 1,311, = 22.13) and general community adults from Canada (Study 2, = 1,506, = 36.80) completed measures of alcohol problems, PTSD symptoms, delay discounting, alcohol demand, and proportionate alcohol-related reinforcement. Across studies, regression analyses revealed significant main effects of alcohol problems and PTSD symptoms in relation to selected reinforcer pathology indicators, but no significant interactions were present for delay discounting or proportionate alcohol-related reinforcement. Interactions were observed for alcohol consumption at $0 (intensity) and the rate of change in consumption across the demand curve (elasticity; Study 1) and for elasticity and maximum alcohol expenditure (; Study 2), but not in the predicted directions. Higher synergistic severity was associated with lower alcohol reinforcing value in each case. These findings reveal expected relations between reinforcer pathology indicators and both alcohol problems and PTSD symptomatology in general but did not support the hypothesized synergistic relationship. The relation between alcohol problems and PTSD is more complex than predicted by existing extensions of the reinforcer pathology model, warranting further investigation. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
一种行为经济学强化物病理学模型提出,酒精问题受到陡峭的延迟折扣、对酒精强化作用的过度高估以及无酒精活动的低强化作用影响。将这一观点扩展到酒精问题与创伤后应激障碍(PTSD)的共病情况,本研究检验了以下假设:酒精问题和PTSD症状严重程度会相互作用,并与这三个领域的指标呈正相关。来自北美的高风险新兴成年人(研究1,(n = 1311),(M = 22.13))和来自加拿大的普通社区成年人(研究2,(n = 1506),(M = 36.80))完成了关于酒精问题、PTSD症状、延迟折扣、酒精需求以及与酒精相关的强化作用比例的测量。在各项研究中,回归分析揭示了酒精问题和PTSD症状在选定的强化物病理学指标方面的显著主效应,但在延迟折扣或与酒精相关的强化作用比例方面没有显著的相互作用。在0美元时的酒精消费量(强度)以及需求曲线上消费量的变化率(弹性;研究1)以及弹性和最大酒精支出(;研究2)方面观察到了相互作用,但并非在预测的方向上。在每种情况下,更高的协同严重程度与更低的酒精强化价值相关。这些发现总体上揭示了强化物病理学指标与酒精问题和PTSD症状学之间的预期关系,但不支持假设的协同关系。酒精问题与PTSD之间的关系比强化物病理学模型现有扩展所预测的更为复杂,需要进一步研究。(PsycInfo数据库记录(c)2024美国心理学会,保留所有权利)