Monsorno Katia, Buckinx An, Paolicelli Rosa C
Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Trends Endocrinol Metab. 2022 Mar;33(3):186-195. doi: 10.1016/j.tem.2021.12.001. Epub 2022 Jan 4.
Microglia, the resident macrophages of the central nervous system (CNS), play important functions in the healthy and diseased brain. In the emerging field of immunometabolism, progress has been made in understanding how cellular metabolism can orchestrate the key responses of tissue macrophages, such as phagocytosis and inflammation. However, very little is known about the metabolic control of microglia. Lactate, now recognized as a crucial metabolite and a central substrate in metabolic flexibility, is emerging not only as a novel bioenergetic fuel for microglial metabolism but also as a potential modulator of cellular function. Parallels with macrophages will help in understanding how microglial lactate metabolism is implicated in brain physiology and pathology, and how it could be targeted for therapeutic purposes.
小胶质细胞作为中枢神经系统（CNS）的常驻巨噬细胞，在健康和患病的大脑中发挥着重要作用。在新兴的免疫代谢领域，人们在理解细胞代谢如何协调组织巨噬细胞的关键反应（如吞噬作用和炎症反应）方面取得了进展。然而，对于小胶质细胞的代谢调控却知之甚少。乳酸现在被认为是一种关键代谢物和代谢灵活性的核心底物，它不仅作为小胶质细胞代谢的一种新型生物能量燃料出现，还作为细胞功能的潜在调节剂出现。与巨噬细胞的相似之处将有助于理解小胶质细胞乳酸代谢如何与脑生理学和病理学相关联，以及如何将其作为治疗靶点。
