[Stability of tissue plasminogen activator].

Stability of the tissue activator plasminogen was studied in various experimental conditions in vitro. The enzyme did not loss its activity after 3 hrs incubation and 7-fold dilution with physiological saline. Blood plasma, added to the tissue activator plasminogen preparation, decreased twice the enzyme activity even without preincubation. In blood plasma, obtained within 1 min after intravenous administration of the activator preparation, inhibition of the enzyme occurred during all the period of incubation and it was more pronounced.