携带 和 突变的去势抵抗性前列腺癌患者中，循环肿瘤 DNA 假阳性结果不能解释 PARP 抑制剂疗效缺乏的原因。
False-Positive Circulating Tumor DNA Results Do Not Explain Lack of Efficacy for PARP Inhibitors in Patients With Castration-Resistant Prostate Cancer Harboring and Mutations.
机构信息
Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, MD.
Oncology Center of Excellence (OCE), U.S. Food and Drug Administration, Silver Spring, MD.
出版信息
JCO Precis Oncol. 2024 Aug;8:e2400354. doi: 10.1200/PO.24.00354.
Abstract
False-positive ctDNA results do not explain lack of efficacy for PARPi in patients with ATMm and CHEK2m CRPC.
摘要
假阳性 ctDNA 结果并不能解释 ATMm 和 CHEK2m CRPC 患者中 PARPi 无效的原因。
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