Institute of food safety, Chinese Academy of Inspection and Quarantine, Beijing, 100176, China; School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Key Laboratory of Food Quality and Safety, State Administration for Market Regulation, Beijing, 100176, China.
Institute of food safety, Chinese Academy of Inspection and Quarantine, Beijing, 100176, China; Key Laboratory of Food Quality and Safety, State Administration for Market Regulation, Beijing, 100176, China.
Food Chem. 2025 Jan 1;462:140666. doi: 10.1016/j.foodchem.2024.140666. Epub 2024 Aug 10.
To improve the adsorption affinity and selectivity of fipronils (FPNs), including fipronil, its metabolites and analogs, a magnetic covalent organic framework (FeO@COF-F) with copious fluorine affinity sites was innovatively designed as an adsorbent of magnetic solid-phase extraction (MSPE). The enhanced surface area, pore size, crystallinity of FeO@COF-F and its exponential adsorption capacities (187.3-231.5 mg g) towards fipronils were investigated. Combining MSPE with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), an analytical method was established for the selective determination of fipronils in milk and milk powder samples. This method achieved high sensitivity (LODs: 0.004-0.075 ng g), satisfactory repeatability and accuracy with spiked recoveries ranging from 89.9% to 100.3% (RSDs≤5.1%). Overall, the constructed FeO@COF-F displayed great potential for the selective enrichment of fipronils, which could be ascribed to fluorine‑fluorine interaction. This method proposed a feasible and promising strategy for the development of functionalized COF and broadened its application in fluorine containing hazards detection.
为了提高氟虫腈（FPNs）及其代谢物和类似物的吸附亲和力和选择性，创新性地设计了一种具有丰富氟亲和力位点的磁性共价有机框架（FeO@COF-F）作为磁性固相萃取（MSPE）的吸附剂。研究了 FeO@COF-F 的比表面积、孔径、结晶度的增强以及其对氟虫腈的指数吸附容量（187.3-231.5 mg g）。结合高效液相色谱-串联质谱（HPLC-MS/MS），建立了一种用于牛奶和奶粉样品中氟虫腈选择性测定的分析方法。该方法具有较高的灵敏度（LODs：0.004-0.075 ng g）、令人满意的重复性和准确性，加标回收率在 89.9%至 100.3%之间（RSDs≤5.1%）。总的来说，所构建的 FeO@COF-F 对氟虫腈的选择性富集具有很大的潜力，这可以归因于氟-氟相互作用。该方法为功能化 COF 的开发提出了一种可行且有前途的策略，并拓宽了其在含氟危害检测中的应用。
