戴克奖。脑脓肿模型中对比增强磁共振成像的评估。
Dyke Award. Evaluation of contrast-enhanced MR imaging in a brain-abscess model.
作者信息
Runge V M, Clanton J A, Price A C, Herzer W A, Allen J H, Partain C L, James A E
出版信息
AJNR Am J Neuroradiol. 1985 Mar-Apr;6(2):139-47.
An alpha-streptococcus brain abscess was produced in five dogs and studied with magnetic resonance (MR) imaging (0.5 T) and computed tomography (CT). Non-contrast- and contrast-enhanced CT scans were obtained using gadolinium diethylenetriamine-pentaacetic acid (Gd DTPA) for MR imaging and meglumine iothalamate for CT scanning. Each animal was evaluated in the early and later cerebritis stages of abscess evolution. On MR, the area of cerebritis enhanced after administration of Gd DTPA in a manner similar to that observed with contrast-enhanced CT. However, contrast enhancement was greater on the MR examination. Early lesions in two animals were detected only with contrast-enhanced MR imaging. This experience suggests that intravenously administered agents such as Gd DTPA should increase the diagnostic potential of MR imaging in neurologic diseases, especially those altering the blood-brain barrier.
在五只狗身上制造了甲型链球菌脑脓肿，并使用磁共振（MR）成像（0.5T）和计算机断层扫描（CT）进行研究。使用钆二乙烯三胺五乙酸（Gd DTPA）进行MR成像，使用碘海醇葡甲胺进行CT扫描，分别获得了非增强和增强CT扫描图像。在脓肿演变的早期和后期脑炎阶段对每只动物进行评估。在MR上，给予Gd DTPA后，脑炎区域的强化方式与增强CT观察到的相似。然而，MR检查中的对比增强更大。两只动物的早期病变仅通过增强MR成像检测到。该经验表明，静脉注射的药物如Gd DTPA应可提高MR成像在神经系统疾病中的诊断潜力，尤其是那些改变血脑屏障的疾病。
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