Department of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an Honghui Hospital North District, Xi'an, Shaanxi 710000, China.
Department of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an Honghui Hospital North District, Xi'an, Shaanxi 710000, China.
Int J Biol Macromol. 2024 Nov;279(Pt 1):135146. doi: 10.1016/j.ijbiomac.2024.135146. Epub 2024 Aug 30.
Osteoarthritis (OA) represents a chronic degenerative joint ailment characterized by the gradual breakdown of cartilage, inflicting substantial physical and economic burdens, especially among the elderly. Given the incomplete understanding of OA's pathogenesis, there is an increasing need to develop targeted therapeutic strategies and preventive measures. Conventional pharmaceutical interventions, such as non-steroidal anti-inflammatory drugs, steroids, and opioids, though effective, are often accompanied by notable adverse effects, thus emphasizing the urgency in seeking safer and more efficient therapeutic alternatives. The rapid evolution of nanotechnology has opened the door to various nanosystems for drug delivery, offering a promising avenue to mitigate these side effects. Of particular interest, recent research has shed light on the significant potential of polysaccharide-based nanosystems in the context of OA therapy, demonstrating their capability to counter inflammation, oxidative stress, regulate chondrocyte metabolism and proliferation, and protect cartilage. Therefore, in this review, we provide an in-depth examination of the role of polysaccharide nanosystems in OA, focusing on summarizing these findings based on different mechanisms of action. Furthermore, this review explores the application of combined polysaccharide nanosystems in OA, aiming to establish a foundation for the utilization of novel drug delivery nanoplatforms in OA treatment, ultimately expanding therapeutic options for this debilitating condition.
骨关节炎（OA）是一种慢性退行性关节疾病，其特征是软骨逐渐退化，给患者带来了巨大的身体和经济负担，尤其是老年人。鉴于对 OA 发病机制的不完全了解，越来越需要开发针对该疾病的治疗策略和预防措施。传统的药物干预，如非甾体抗炎药、类固醇和阿片类药物，虽然有效，但往往伴随着明显的不良反应，因此强调了寻找更安全、更有效的治疗替代方法的紧迫性。纳米技术的快速发展为药物输送的各种纳米系统开辟了道路，为减轻这些副作用提供了有希望的途径。特别值得关注的是，最近的研究揭示了多糖基纳米系统在 OA 治疗中的重要潜力，表明它们能够对抗炎症、氧化应激、调节软骨细胞代谢和增殖，以及保护软骨。因此，在这篇综述中，我们深入探讨了多糖纳米系统在 OA 中的作用，重点总结了基于不同作用机制的这些发现。此外，本综述还探讨了联合多糖纳米系统在 OA 中的应用，旨在为新型药物输送纳米平台在 OA 治疗中的应用奠定基础，最终为这种使人衰弱的疾病提供更多的治疗选择。
