利用纳米孔测序技术对狐狸死亡病例进行快速诊断，发现感染了一种类似北极型狂犬病病毒。
Rapid diagnosis of a fox's death case using nanopore sequencing reveals the infection with an Artic-like rabies virus.
作者信息
Liu Yuhang, Liu Zhiqiang, Li Jian, Yan Xiaomin, Xu Weidi, Yi Le, Tu Changchun, He Biao
机构信息
Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China.
Provincial Wildlife Disease Monitoring Station of Shuanghe, Xunke, 164400, China.
出版信息
Virol Sin. 2024 Oct;39(5):840-842. doi: 10.1016/j.virs.2024.08.010. Epub 2024 Aug 27.
• We detected a rabies virus (RABV) in a fox's death case within 6 h upon sample receipt using nanopore direct sequencing. • The virus belongs to AL2 sub-lineage, suggesting a high risk of fox-related AL2 RABV on the northeastern border of China. • Nanopore sequencing showed less sensitivity and accuracy, though it helped us rapidly identify the cause of death.
• 我们在收到样本后的6小时内，通过纳米孔直接测序在一只狐狸的死亡病例中检测到了狂犬病病毒（RABV）。
• 该病毒属于AL2亚谱系，这表明在中国东北边境存在与狐狸相关的AL2型狂犬病病毒的高风险。
• 尽管纳米孔测序帮助我们迅速确定了死亡原因，但其灵敏度和准确性较低。
Zotero 插件