Sabrin Sumyea, Hong Sung-Ha, Karmokar Debabrata K, Habibullah Habibullah, Fitridge Robert, Short Robert D, Szili Endre J
Future Industries Institute, University of South Australia, Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia.
Future Industries Institute, University of South Australia, Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia.
Trends Biotechnol. 2025 Feb;43(2):278-289. doi: 10.1016/j.tibtech.2024.07.013. Epub 2024 Aug 28.
Chronic wound infections are a silent pandemic in danger of becoming a global healthcare crisis. Innovations to control infections and improve healing are required. In the context of this challenge, researchers are exploiting plasma-activated hydrogel therapy (PAHT) for use either alone or in combination with other antimicrobial strategies. PAHT involves the cold atmospheric pressure plasma activation of hydrogels with reactive oxygen and nitrogen species to decontaminate infections and promote healing. This opinion article describes PAHT for wound treatment and provides an overview of current research and outstanding challenges in translating the technology for medical use. A 'blueprint' of an autonomous PAHT is presented in the final section that can move the management and treatment of wounds from the clinical setting to the community.
慢性伤口感染是一场无声的大流行疾病，有演变成全球医疗危机的风险。需要创新方法来控制感染并促进伤口愈合。在这一挑战背景下，研究人员正在探索单独使用或与其他抗菌策略联合使用的等离子体活化水凝胶疗法（PAHT）。PAHT是指利用活性氧和氮物质对水凝胶进行冷大气压等离子体活化，以清除感染并促进愈合。这篇观点文章介绍了用于伤口治疗的PAHT，并概述了将该技术转化为医学应用的当前研究和突出挑战。最后一部分展示了一个自主PAHT的“蓝图”，它可以将伤口的管理和治疗从临床环境转移到社区。
