固定义齿修复患者龈沟液细胞因子谱：系统评价和荟萃分析。

Cytokines profile in gingival crevicular fluid of subjects wearing fixed dental prostheses: a systematic review and meta-analysis.

机构信息

Biomedical Science, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, 39090, Chilpancingo de los Bravo, Guerrero, Mexico.

Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, India.

出版信息

Eur J Med Res. 2024 Aug 29;29(1):437. doi: 10.1186/s40001-024-02031-y.

DOI:10.1186/s40001-024-02031-y

PMID:39210386

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11360320/

Abstract

BACKGROUND

Fixed dental prostheses (FDP) can affect the production of inflammatory cytokines causing damage to periodontal tissues. A systematic review and meta-analysis was carried out with the following two objectives: (1) to determine the prevalence and function of the different inflammatory cytokines present in gingival crevicular fluid (GCF) of teeth with metal-ceramic (M/C) and all-ceramic (A-Cs) prostheses, and (2) to analyze and compare the levels of inflammatory cytokines in GCF of teeth with M/C and A-Cs prostheses.

METHODS

The protocol followed PRISMA and Cochrane guidelines and was registered in the OSF:10.17605/OSF.IO/RBHJU. A digital search was conducted in the databases PubMed/MEDLINE, Cochrane Library, Dentistry & Oral Sciences Source, Scopus, Web of Science, ScienceDirect, and Google Scholar, from July 15th, 2000 to March 1st, 2024. Study quality was assessed using the JBI tool for cross-sectional and longitudinal studies. A meta-analysis was performed using a random-effects model to evaluate the concentration of IL-1β in GCF of teeth with FDP of M/C and A-Cs.

RESULTS

The search strategy provided a total of 8,172 articles, of which 14 investigations met the inclusion criteria. The total number of patients studied was 468 of whom 53% were women and the rest (47%) were men. The ages of the patients ranged from 19 to 73 years, with a mean age ± standard deviation (SD) of 38,5 ± 12,8 years. A total of 843 fixed dental prostheses were studied, of which 407 (48,27%) were M/C prostheses and 410 (48,63%) were A-Cs prostheses. We found that the levels of IL-1β, IL-1α, PGE, NKA, CGRP, and CX3CL1 were increased in teeth with M/C prostheses compared to teeth with A-Cs prostheses. Meta-analysis revealed that there are no significant differences between IL-1β levels in GCF in teeth with M/C prostheses compared to teeth with A-Cs prostheses (SMD = 13.89 pg/ml (CI = -14.29-42.08), p = > 0.05).

CONCLUSIONS

A trend toward increased levels of inflammatory cytokines was found in GCF of teeth with M/C prostheses compared to teeth with A-Cs prostheses.

摘要

背景

固定义齿（FDP）可影响炎性细胞因子的产生，从而导致牙周组织损伤。本研究进行了系统评价和荟萃分析，旨在：（1）确定金属陶瓷（M/C）和全陶瓷（A-Cs）修复体牙的龈沟液（GCF）中存在的不同炎性细胞因子的流行率和功能；（2）分析和比较 M/C 和 A-Cs 修复体牙的 GCF 中炎性细胞因子的水平。

方法

本研究遵循 PRISMA 和 Cochrane 指南，并在 OSF 上进行注册：10.17605/OSF.IO/RBHJU。于 2000 年 7 月 15 日至 2024 年 3 月 1 日，在 PubMed/MEDLINE、Cochrane 图书馆、牙科学与口腔科学资源、Scopus、Web of Science、ScienceDirect 和 Google Scholar 数据库中进行了数字检索。使用 JBI 工具评估横断面和纵向研究的研究质量。使用随机效应模型进行荟萃分析，以评估 FDP 为 M/C 和 A-Cs 的牙的 GCF 中 IL-1β 的浓度。

结果

搜索策略共提供了 8172 篇文章，其中 14 项研究符合纳入标准。共纳入了 468 名患者，其中 53%为女性，其余（47%）为男性。患者年龄为 19-73 岁，平均年龄±标准差（SD）为 38.5±12.8 岁。共研究了 843 个固定义齿，其中 407 个（48.27%）为 M/C 义齿，410 个（48.63%）为 A-Cs 义齿。我们发现，与 A-Cs 义齿相比，M/C 义齿的牙的 IL-1β、IL-1α、PGE、NKA、CGRP 和 CX3CL1 水平升高。荟萃分析显示，M/C 义齿牙的 GCF 中 IL-1β 水平与 A-Cs 义齿牙之间无显著差异（SMD=13.89 pg/ml（CI=-14.29-42.08），p>0.05）。