卡托普利、硝酸盐类药物及普萘洛尔对肝脏表观血流量的影响。
The influence of captopril, the nitrates and propranolol on apparent liver blood flow.
作者信息
Shepherd A N, Hayes P C, Jacyna M, Morrison L, Bouchier I A
出版信息
Br J Clin Pharmacol. 1985 Mar;19(3):393-7. doi: 10.1111/j.1365-2125.1985.tb02659.x.
Abstract
Indocyanine green estimated apparent liver blood flow was measured in normal volunteers following glyceryl trinitrate, propranolol, isosorbide mononitrate and captopril. Glyceryl trinitrate and propranolol significantly reduced apparent liver blood flow. Isosorbide mononitrate did not alter apparent liver blood flow or produce an additional reduction in apparent liver blood flow when combined with propranolol. Captopril did not alter apparent liver blood flow despite a significant fall in mean arterial pressure and rise in plasma renin activity. Captopril and isosorbide mononitrate if shown to reduce portal pressure, do so without a fall in apparent liver blood flow.
摘要
在正常志愿者中，分别给予硝酸甘油、普萘洛尔、单硝酸异山梨酯和卡托普利后，测量了吲哚菁绿估计的表观肝血流量。硝酸甘油和普萘洛尔显著降低了表观肝血流量。单硝酸异山梨酯未改变表观肝血流量，与普萘洛尔联合使用时也未使表观肝血流量进一步降低。尽管平均动脉压显著下降且血浆肾素活性升高，但卡托普利并未改变表观肝血流量。如果卡托普利和单硝酸异山梨酯能降低门静脉压力，那么它们是在不降低表观肝血流量的情况下做到的。
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