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Nifedipine increases and glyceryl trinitrate decreases apparent liver blood flow in normal subjects.硝苯地平可增加正常受试者的肝脏表观血流量，而硝酸甘油则使其降低。
Br J Clin Pharmacol. 1984 Jan;17(1):83-5. doi: 10.1111/j.1365-2125.1984.tb05003.x.
2
Effect of the combination of alinidine and other anti-anginal drugs on heart rate and blood pressure in healthy volunteers.阿利尼定与其他抗心绞痛药物联合应用对健康志愿者心率和血压的影响。
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The influence of nifedipine and captopril on liver blood flow in healthy subjects.硝苯地平和卡托普利对健康受试者肝血流量的影响。
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本文引用的文献

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The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function.吲哚菁绿在肝血流测量及肝功能检测中的应用。
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Prazosin and hydralazine in congestive heart failure. Regional hemodynamic effects in relation to dose.
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Effect of hypotension on liver blood flow and lidocaine disposition.低血压对肝脏血流及利多卡因处置的影响。
N Engl J Med. 1982 Sep 30;307(14):866-9. doi: 10.1056/NEJM198209303071406.
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Cimetidine alters plasma catecholamine levels and cortisol and aldosterone excretion.西咪替丁会改变血浆儿茶酚胺水平以及皮质醇和醛固酮的排泄。
N Engl J Med. 1982 Apr 29;306(17):1054. doi: 10.1056/NEJM198204293061716.
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The effect of indoramin infusion on apparent liver blood flow in man.吲哚拉明输注对人体肝脏表观血流量的影响。
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6
Nitroglycerin improves the hemodynamic response to vasopressin in portal hypertension.硝酸甘油可改善门静脉高压症患者对血管加压素的血流动力学反应。
Hepatology. 1982 Nov-Dec;2(6):757-62. doi: 10.1002/hep.1840020602.
7
Calcium antagonists, nitrates, and new antianginal drugs.钙拮抗剂、硝酸盐类药物及新型抗心绞痛药物。
Br Med J (Clin Res Ed). 1983 Apr 2;286(6371):1127-30. doi: 10.1136/bmj.286.6371.1127.
8
Physiological and pharmacological variability in estimated hepatic blood flow in man.人体肝脏血流估计中的生理和药理变异性。
Br J Clin Pharmacol. 1981 May;11(5):491-6. doi: 10.1111/j.1365-2125.1981.tb01155.x.
9
Interrelationships of hepatic blood flow, cardiac output, and blood levels of lidocaine in man.人体肝脏血流量、心输出量与利多卡因血药浓度之间的相互关系。
Circulation. 1971 Feb;43(2):205-11. doi: 10.1161/01.cir.43.2.205.
10
Minoxidil increases aldosterone metabolic clearance in hypertensive patients.米诺地尔可增加高血压患者醛固酮的代谢清除率。
J Clin Endocrinol Metab. 1979 Dec;49(6):834-7. doi: 10.1210/jcem-49-6-834.

硝苯地平可增加正常受试者的肝脏表观血流量，而硝酸甘油则使其降低。

Nifedipine increases and glyceryl trinitrate decreases apparent liver blood flow in normal subjects.

作者信息

Feely J

出版信息

Br J Clin Pharmacol. 1984 Jan;17(1):83-5. doi: 10.1111/j.1365-2125.1984.tb05003.x.

DOI:10.1111/j.1365-2125.1984.tb05003.x
PMID:6419762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463307/
Abstract

The effects of sublingual nifedipine (10 mg) and of glyceryl trinitrate (500 micrograms), which produce arterial and venous vasodilatation respectively, on indocyanine green estimated apparent liver blood flow (LBF) were studied in six healthy volunteers. Nifedipine significantly increased (33 +/- 12%; mean +/- s.e. mean) and glyceryl trinitrate significantly reduced (18 +/- 3%) LBF. There was a positive relationship (r = 0.92, P less than 0.05) between the reduction in mean arterial pressure produced by nifedipine and the percentage increase in LBF. These results show that single doses of nifedipine and glyceryl trinitrate significantly alter LBF.

摘要

分别研究了舌下含服硝苯地平（10毫克）和硝酸甘油（500微克）对6名健康志愿者经吲哚菁绿估算的表观肝血流量（LBF）的影响，这两种药物分别引起动脉和静脉血管扩张。硝苯地平使LBF显著增加（33±12%；平均值±标准误平均值），硝酸甘油使LBF显著降低（18±3%）。硝苯地平引起的平均动脉压降低与LBF增加百分比之间存在正相关关系（r = 0.92，P<0.05）。这些结果表明，单剂量的硝苯地平和硝酸甘油可显著改变LBF。