硝苯地平可增加正常受试者的肝脏表观血流量，而硝酸甘油则使其降低。
Nifedipine increases and glyceryl trinitrate decreases apparent liver blood flow in normal subjects.
作者信息
Feely J
出版信息
Br J Clin Pharmacol. 1984 Jan;17(1):83-5. doi: 10.1111/j.1365-2125.1984.tb05003.x.
Abstract
The effects of sublingual nifedipine (10 mg) and of glyceryl trinitrate (500 micrograms), which produce arterial and venous vasodilatation respectively, on indocyanine green estimated apparent liver blood flow (LBF) were studied in six healthy volunteers. Nifedipine significantly increased (33 +/- 12%; mean +/- s.e. mean) and glyceryl trinitrate significantly reduced (18 +/- 3%) LBF. There was a positive relationship (r = 0.92, P less than 0.05) between the reduction in mean arterial pressure produced by nifedipine and the percentage increase in LBF. These results show that single doses of nifedipine and glyceryl trinitrate significantly alter LBF.
摘要
分别研究了舌下含服硝苯地平（10毫克）和硝酸甘油（500微克）对6名健康志愿者经吲哚菁绿估算的表观肝血流量（LBF）的影响，这两种药物分别引起动脉和静脉血管扩张。硝苯地平使LBF显著增加（33±12%；平均值±标准误平均值），硝酸甘油使LBF显著降低（18±3%）。硝苯地平引起的平均动脉压降低与LBF增加百分比之间存在正相关关系（r = 0.92，P<0.05）。这些结果表明，单剂量的硝苯地平和硝酸甘油可显著改变LBF。
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