Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, China.
Department of Rheumatology & Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China.
Eur J Med Res. 2024 Aug 29;29(1):439. doi: 10.1186/s40001-024-02013-0.
A correlation exists between lipids and osteoporosis (OP), as well as between lipids and rheumatoid arthritis (RA). However, lipids, the relationship between RA and OP is still unclear. This study mainly investigates the relationship between lipid levels and OP risk in RA patients.
Retrospective collection of RA patient data from July 2017 to May 2022, encompassing baseline demographics, treatment regimens, laboratory results, and bone mineral density (BMD) measurements. Analyses, stratified by BMD subgroups, were conducted using propensity score matching (PSM) based on age, sex, and baseline duration, and binary logistic regression to examine the interplay between lipoprotein levels and other risk factors. The relationship between continuous variables and OP risk was assessed using restricted cubic spline (RCS), followed by a reanalysis of the correlation between varying lipoprotein levels and different factors, segmented according to RCS-determined cutoffs.
The study included 2673 RA patients. Binary logistic regression revealed significant associations between high-density lipoprotein (HDL), low-density lipoprotein (LDL), and RA-OP (p < 0.01). Specifically, HDL emerged as a protective factor against OP (OR = 0.40, 95% CI 0.250-0.629; p < 0.001), whereas LDL was identified as a risk factor (OR = 1.56, 95% CI 1.290-1.890; p < 0.001). Furthermore, HDL (RCS cutoff point 1.28 mmol/L) showed a negative, linear correlation with RA-related OP, while LDL (RCS cutoff point 2.63 mmol/L) demonstrated a positive, linear correlation.
The levels of HDL and LDL may be indicators of OP occurrence in RA patients.
脂质与骨质疏松症（OP）以及脂质与类风湿关节炎（RA）之间存在相关性。然而，脂质与 RA 和 OP 之间的关系尚不清楚。本研究主要探讨 RA 患者血脂水平与 OP 风险的关系。
回顾性收集 2017 年 7 月至 2022 年 5 月的 RA 患者数据，包括基线人口统计学、治疗方案、实验室结果和骨密度（BMD）测量值。采用倾向评分匹配（PSM）对年龄、性别和基线持续时间进行分层分析，并采用二元逻辑回归分析脂蛋白水平与其他危险因素之间的相互关系。采用受限立方样条（RCS）评估连续变量与 OP 风险的关系，然后根据 RCS 确定的切点对不同脂蛋白水平与不同因素的相关性进行重新分析。
本研究共纳入 2673 例 RA 患者。二元逻辑回归显示，高密度脂蛋白（HDL）、低密度脂蛋白（LDL）与 RA-OP 之间存在显著相关性（p<0.01）。具体而言，HDL 是 OP 的保护因素（OR=0.40，95%CI 0.250-0.629；p<0.001），而 LDL 是危险因素（OR=1.56，95%CI 1.290-1.890；p<0.001）。此外，HDL（RCS 切点 1.28 mmol/L）与 RA 相关 OP 呈负线性相关，而 LDL（RCS 切点 2.63 mmol/L）与 RA 相关 OP 呈正线性相关。
HDL 和 LDL 水平可能是 RA 患者 OP 发生的指标。
