Wei Xu, Zhang Yili, Sun Chuanrui, Qi Baoyu, Huang Xinyi, Chen Ming, Liu Ning, Sun Kai, Chen Xin, Qin Xiaokuan, Xie Yanming, Zhu Liguo
Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Institute of Orthopaedics of Beijing Integrative Medicine, Beijing, China.
Front Cardiovasc Med. 2022 Sep 14;9:901786. doi: 10.3389/fcvm.2022.901786. eCollection 2022.
A previous study has shown similar factors in dyslipidemias (DL) and osteoporosis (OP). However, no cohort study has been reported on the association between DL and OP in the postmenopausal population in China. This study aims to provide epidemiological and pathophysiological evidence regarding the association between DL and bone mass and fracture risk.
This is a multicenter, prospective cohort study that will have approximately 1,100 representative participants enrolled from multiple hospitals or communities in China. They will be divided into two groups according to whether or not they are exposed to dyslipidemia and will be epidemiologically investigated. Each participant will be visited continuously once every year with a minimum follow-up of 3 years to track incidences of OP. Meanwhile, free bone density screening, questionnaires, and blood sample collection will also be completed during this period.
The current study is likely to provide greater insight into the relationship between lipid metabolism and bone metabolism in postmenopausal women. Furthermore, the research result maybe fed into public health strategies with regard to metabolic disease prevention.
先前的一项研究显示血脂异常（DL）和骨质疏松症（OP）存在相似的因素。然而，在中国绝经后人群中，尚未有关于DL与OP之间关联的队列研究报道。本研究旨在提供关于DL与骨量及骨折风险之间关联的流行病学和病理生理学证据。
这是一项多中心前瞻性队列研究，将从中国多家医院或社区招募约1100名具有代表性的参与者。他们将根据是否患有血脂异常分为两组，并进行流行病学调查。每位参与者每年将接受一次随访，最少随访3年以跟踪OP的发病率。同时，在此期间还将完成免费的骨密度筛查、问卷调查和血液样本采集。
本研究可能会更深入地了解绝经后女性脂质代谢与骨代谢之间的关系。此外，研究结果可能会纳入代谢性疾病预防的公共卫生策略中。
