Department of Biochemistry, Hopkins Building, Tennis Court Road, Cambridge, CB2 1QW, Cambridge, UK.
Microbiology (Reading). 2024 Aug;170(8). doi: 10.1099/mic.0.001495.
In this opinion piece, we consider the meaning of the term 'wild type' in the context of microbiology. This is especially pertinent in the post-genomic era, where we have a greater awareness of species diversity than ever before. Genomic heterogeneity, evolution/selection pressures, definition of 'the wild', the size and importance of the pan-genome, gene-gene interactions (epistasis), and the nature of the 'wild-type gene' are all discussed. We conclude that wild type is an outdated and even misleading phrase that should be gradually phased out.
在这篇观点文章中，我们考虑了“野生型”一词在微生物学中的含义。在后基因组时代，我们比以往任何时候都更加意识到物种多样性，这一点尤其重要。我们讨论了基因组异质性、进化/选择压力、“野生”的定义、泛基因组的大小和重要性、基因-基因相互作用（上位性）以及“野生型基因”的性质。我们的结论是，“野生型”是一个过时甚至是误导性的短语，应该逐步淘汰。
